Circulating lncRNA MHRT predicts survival of patients with chronic heart failure
Lie ZHANG1
Yan-Jun WU2
Sui-Long ZHANG1
1.Department of Geriatric Cardiovascular Disease,the Second Affiliated Hospital of Xi'an Jiaotong University,Xian,China 2.Department of General Surgery,Xi'an Northern Hospital,Xian,China
摘要：Background It has been reported that lncRNA myosin heavy-chain-associated RNA transcripts(MHRT)can inhibit the apoptosis of cardiomyocytes.It is one of the major pathological changes leading to chronic heart failure.Methods The expression level of lncRNA MHRT was assessed by qRT-PCR.Diagnostic values of lncRNA MHRT for chronic heart failure were analyzed by ROC curve analysis.Cell apoptosis was detected by cell apoptosis assay.Results The results demonstrated that expression of lncRNA MHRT in plasma was down-regulated in patients with chronic heart failure compared to that in healthy people.Down-regulation of lncRNA NHRT distinguished chronic heart failure from healthy people.Over-expression of lncRNA MHRT inhibited the apoptosis of human cardiomyocyte cell line AC16 after H2O2 treatment.Follow-up study showed that chronic heart failure patients with lower expression levels of lncRNA MHRT had worse survival conditions compared to patients with higher expression levels of lncRNA MHRT.Conclusion We concluded that circulating lncRNA MHRT might serve as a diagnostic and prognostic marker for chronic heart failure treatment.
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论文发表日期：2019-11-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 818-821 )
英文信息