Association between serum cartilage oligomeric matrix protein and coronary artery calcification in maintenance hemodialysis patients
Lahati HA1
Jun-Bao SHI2
Hai-Yi YU1
Kun YANG3
Hai-Ning WANG3
Fang-Fang WANG1
Jiang-Li HAN1
1.Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing, China2.Department of Nephrology, Peking University Third Hospital, Beijing, China3.Department of Endocrinology, Peking University Third Hospital, Beijing, China
摘要：Background Coronary artery calcification (CAC) is common in end-stage renal disease (ESRD) patients,and the extent of CAC is closely related to cardiovascular outcomes in ESRD patients.Cartilage oligomeric matrix protein (COMP),as a component of the vascular matrix,has been found to be an inhibitor of arterial calcification in basic studies.However,there is no clinical research on the correlation between COMP and CAC in maintenance hemodialysis (MHD) patients.The aim of this study was to explore the relationship between serum COMP levels and CAC and cardiovascular events in MHD patients.Methods Serum COMP levels were compared between 54 MHD patients and 66 healthy people.MHD patients were then divided into three groups according to the tertiles of the concentration of COMP level and were followed up for major adverse cardiac events (MACEs),which were defined as a combined end point of new onset angina pectoris,nonfatal myocardial infarction,heart failure,coronary artery revascularization,hospitalization due to angina pectoris and all-cause deaths.The CAC score was calculated based on computed tomography scans.Results The serum COMP level in MHD patients was significantly higher than that in the general population [984.23 (248.43-1902.61) ng/mL vs.219.01 (97.26-821.92) ng/mL,P ＜ 0.01].Serum COMP levels were positively correlated with CAC (r =0.313,P =0.021) and serum parathyroid hormone in MHD patients (r =0.359,P ＜ 0.01).Linear regression suggested that after adjusting for age,fasting blood glucose (Glu) and glycosylated hemoglobin (HbAlc),CAC score was an independent predictor in the final model for COMP level (β =0.424,t =3.130,P ＜ 0.01).The receiver operating characteristic (ROC) curve showed that COMP ≥ 994 mg/mL had 68.0％ sensitivity and 72.4％ specificity for the prediction of severe CAC [area under the curve (AUC):0.674,P =0.030,95％ CI:0.526-0.882].After a median follow-up of 16 months (8-24 months),there was no difference in the incidence rate of MACEs between the upper,middle and lower serum COMP groups.Conclusions Our study found that MHD patients have higher levels of circulating COMP than controls.The serum COMP level is positively correlated with CAC score and could be used as a biomarker of severe CAC in MHD patients.However,there is no obvious correlation between serum COMP levels and the incidence of cardiovascular events.
机标关键词：
论文发表日期：2020-02-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 67-73 )
英文信息