Association of atherosclerotic plaque features with collateral circulation status in elderly patients with chronic carotid stenosis
Hui-Min XU1
Ran HUO1
Rui-Jing XIN2
Dan-Dan YANG3
Ying LIU1
Ning LANG1
Xi-Hai ZHAO4
Tao WANG5
Hui-Shu YUAN1
1.Department of Radiology, Peking University Third Hospital, Beijing, China2.Department of Radiology, Zhongda Hospital, Medical School of Southeast University, Nanjing, China3.Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders,Capital Medical University, Beijing, China;Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University School of Medicine, Beijing, China4.Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University School of Medicine, Beijing, China5.Department of Neurosurgery, Peking University Third Hospital, Beijing, China
摘要：Objective To determine the association of carotid plaque features with collateral circulation status in elderly patients with moderate to severe carotid stenosis.Methods Elderly patients (＞ 60 years) with moderate to severe carotid stenosis were recruited and categorized into good and poor collateral circulation groups,and underwent magnetic resonance imaging and computed tomography imaging.The carotid plaque features including lipid-rich necrotic core,intraplaque hemorrhage,calcification,and fibrous cap rupture (FCR) were evaluated,and maximum wall thickness,normalized wall index (NWI),and luminal stenosis were measured.The association between these variables and collateral circulation status was analyzed.Results Of the 97 patients (78 males,mean age: 69.0 ± 6.1 years),19 (19.6％) had poor collaterals.The poor collateral group had a significantly higher NWI (93.7％ ± 5.0％ vs.89.0％ ± 7.9％,P =0.011),a greater extent of stenosis (80.0％ ± 11.4％ vs.75.3％ ± 9.4％,P =0.036) and FCR (84.2％ vs.55.1％,P =0.020) compared with good collateral group.Carotid NWI (OR =3.83,95％ CI: 1.36-10.82,P =0.011) and more FCR (OR =6.77,95％ CI: 1.35-33.85,P =0.020) were associated with poor collateral circulation after adjustment for the confounding factors.The combination of NWI,FCR,systolic blood pressure,and triglycerides had the highest area-under-the-curve (AUC =0.85) for detection of poor collaterals.Conclusions Carotid plaque features,specifically NWI and FCR,are independently associated with poor collateral circulation,and the combination of carotid plaque features and traditional risk factors has a stronger predictive value for poor collateral circulation than plaque features alone.
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论文发表日期：2020-04-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 202-209 )
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