Growth differentiation factor-15 is a prognostic marker in patients with intermediate coronary artery disease
Wei WANG1
Xian-Tao SONG1
Yun-Dai CHEN2
Fei YUAN1
Feng XU1
Min ZHANG1
Kai TAN1
Xing-Sheng YANG1
Xian-Peng YU1
Kong-Yong CUI1
Shu-Zheng LYU1
1.Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University and Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China2.Department of Cardiology, the First Medical Center of Chinese PLA General Hospital, Beijing, China
摘要：Background Growth differentiation factor-15 (GDF-15) is involved in multiple processes that are associated with coronary artery disease (CAD).However,little is known about the association between GDF-15 and the future ischemic events in patients with intermediate CAD.This study was conducted to investigate whether plasma GDF-15 constituted risk biomarkers for future cardiovascular events in patients with intermediate CAD.Methods A prospective study was performed based on 541 patients with intermediate CAD (20％-70％).GDF-15 of each patient was determined in a blinded manner.The primary endpoint was major adverse cardiac event (MACE),which was defined as a composite of all-cause death,nonfatal myocardial infarction,revascularization and readmission due to angina pectoris.Results After a median follow-up of 64 months,504 patients (93.2％) completed the follow-up.Overall,the combined endpoint of MACE appeared in 134 patients (26.6％) in the overall population: 26 patients died,11 patients suffered a nonfatal myocardial infarction,51 patients underwent revascularization,and 46 patients were readmitted for angina pectoris.The plasma levels of GDF-15 (median: 1172.02 vs.965.25 pg/mL,P =0.014) were higher in patients with ischemic events than those without events.After adjusting for traditional risk factors,higher GDF-15 levels were significantly associated with higher incidence of the composite endpoint of MACE (HR =1.244,95％ CI: 1.048-1.478,Quartile 4 vs.Quartile 1,P =0.013).Conclusions The higher level of GDF-15 was an independent predictor of long-term adverse cardiovascular events in patients with intermediate CAD.
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论文发表日期：2020-04-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 210-216 )
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