Long-term follow-up of antithrombotic management patterns in patients with acute coronary syndrome in China
Xiao-Ning HAN1
Shu-Bin QIAO2
Jun-Bo GE3
Ya-Ling HAN4
Ji-Yan CHEN5
Zu-Yi YUAN6
Bo YU7
Jie JIANG1
Yong HUO1
1.Department of Cardiology, Peking University First Hospital, Beijing, China2.National Center for Cardiovascular Diseases, Fuwai Hospital, Beijing, China3.Department of Cardiology, Zhongshan Hospital Affiliated to Fudan University, Guangzhou, China4.Department of Cardiology, the General Hospital of Shenyang Military, Shenyang, China5.Department of Cardiology, Guangdong General Hospital, Guangzhou, China6.Department of Cardiology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China7.Department of Cardiology, the Second Affiliated Hospital of Harbin Medical University, Harbin, China
摘要：Objective To describe the long-term antithrombotic management pattems (AMPs) and clinical outcomes of Chinese patients with acute coronary syndrome (ACS).Methods This was an observational,multicenter,longitudinal cohort extension study of Chinese patients who had completed the EPICOR Asia 2-year follow-up study post-hospitalization for an ACS event.Changes in AMP and clinical outcomes for up to 5 years post-ACS event were evaluated.Results Overall,2334 patients with ACS were enrolled at 49 sites.The mean age was 61.6 years and 76.3％ were men.By study end,2093 patients completed the 3-year follow-up.At baseline (2 years post-ACS event),72.4％ of patents received one antiplatelet (AP) medication,with aspirin being the preferred one.A small proportion of patients (21.5％) was treated with two or more APs (2+ AP),and even fewer patients (6.1％) did not receive any AP medication at baseline.Upon study completion,the proportion of patients without AP therapy increased to 13.6％,while the percentage of patients on one AP and 2+ AP decreased to 69.3％ and 17.1％,respectively.Numerically,a higher incidence of clinical events (composite of all-cause mortality,myocardial infarction,stroke) was observed for the 2+ AP (13.2％) subgroup than for the no AP (10.5％) and one AP (8.6％) subgroups.Furthermore,the 2+ AP subgroup exhibited the greatest number of bleeding events,outpatient visits,and hospitalization rates.Unlike myocardial infarction or stroke,bleeding events prompted an adjustment in AMP.Conclusion Most patients in China received at least one AP medication up to 5 years after an ACS event.
机标关键词：
论文发表日期：2020-05-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 246-255 )
英文信息