Relationship between high sensitivity C-reactive protein and angiographic severity of coronary artery disease
Nadia Bouzidi1
Mejdi Ben Messaoud2
Faouzi Maatouk3
Habib Gamra2
Salima Ferchichi1
1.University of Monastir, Faculty of Pharmacy, Clinical and Molecular Biology Unit, Monastir, Tunisia2.University of Monastir, Cardiology A Department Fattouma Bourguiba University Hospital, Cardiothrombosis Research Laboratory, Tunisia3.University of Monastir, Cardiology B Department Fattouma Bourguiba University Hospital, Cardiothrombosis Research Laboratory, Tunisia
摘要：Background Coronary artery disease (CAD) remains a leading cause of morbidity and mortality.Cytokines play a potential role in atherosclerosis pathogenesis and progression.We investigated the association between high sensitive C-reactive protein (hsCRP) and severity of CAD.Methods CAD patients were stratified according to hsCRP cut-offvalue into high levels hsCRP group (≥ 8.4 mg/L) and low levels hsCRP group (＜ 8.4 mg/L).Severity of CAD was assessed according to artery stenosis degree and the number of vessel involved.Statistical analysis was performed using Statistical Package for the Social Sciences (SPSS,version 23.0).Results The mean age was 60.3 ± 11.0 years.The level of hsCRP was increased and ranged from 0.2 to 1020.0 mg/L.Biochemical risk factors and severity of CAD didn't show significant differences between the two groups.In multivariate linear analysis,cardiac troponin Ⅰ (cTnⅠ) and serum amyioid A (SAA) were predictors of hsCRP.As shown in receiver operating characteristic (ROC) curve analysis performed in patients with ST-segment elevation myocardial infarction (STEMI) and compared to myonecrosis biomarkers,hsCRP (area under the curve (AUC): 0.905;95％CI: 0.844-0.966;P ＜ 0.001) could be a powerful predictor marker in evaluating the infarct size after myocardial infarction but not better than cTnⅠ.Conclusions HsCRP levels were not associated with the severity of CAD but could be useful in the evaluation of myocardial necrosis in patients with STEMI.
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论文发表日期：2020-05-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 256-263 )
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