Serum microRNA-204 levels are associated with long-term cardiovascular disease risk based on the Framingham risk score in patients with type 2 diabetes:results from an observational study
Rui WANG1
Yao-Dong DING1
Wen GAO2
Yu-Qiang PEI1
Jia-Xin YANG1
Ying-Xin ZHAO1
Xiao-Li LIU1
Hua SHEN1
Shuo ZHANG3
Lei YU4
Hai-Long GE1
1.Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China2.Department of Cardiology, Bayannaoer City Hospital, Inner Mongolia, China3.Department of Gynecology and Obstetrics, Beijing Tiantan Hospital, Capital Medical University, Beijing, China4.Department of Cardiology, the Third Hospital of Jinan, Shandong, China
摘要：Background Previous studies have demonstrated that microRNA-204 (miR-204) is involved in atherosclerosis and vascular calcification.However,the value of miR-204 as the predictive biomarker for cardiovascular disease (CVD) remains unclear.We aimed to evaluate the association between the circulating miR-204 level and ten-year CVD risk based on the Framingham risk score (FRS).Methods In this retrospective study,we enrolled 194 consecutive patients with type 2 diabetes mellitus (T2DM) without CVD in Beijing Anzhen Hospital between January 2015 and September 2016.We used the FRS to evaluate the risk of CVD for each patient.Circulating miR-204 levels were measured by quantitative real-time polymerase chain reaction.Results Circulating miR-204 levels were significantly lower in the group of patients (0.49 ± 0.13) at high risk ofCVD (FRS ＞ 20％) than in the low (FRS ＜ 10％) and intermediate (FRS:10％-20％) risk groups (0.87 ±0.19 and 0.75 ± 0.25,respectively;P ＜ 0.001).FRS was negatively correlated with miR-204 levels (r =-0.421,P ＜ 0.001).According to multivariate logistic analyses,reduced miR-204 level was independently associated with an increased risk of CVD after adjusting for conventional risk factors (OR =0.876,95％ CI:0.807-0.950,P =0.001).Receiver-operating characteristic curve analysis showed that the circulating miR-204 level can predict the high risk of CVD with higher specificity than the traditional risk factor of high systolic blood pressure or the protective factor of high-density lipoprotein cholesterol.Conclusions Our study demonstrated that patients with lower circulating miR-204 levels were at high risk for CVD.After adjustment for potential confounders,miR-204 was independently associated with CVD in patients with T2DM.
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论文发表日期：2020-06-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 330-337 )
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