Increased mortality in elderly heart failure patients receiving infusion of furosemide compared to elderly heart failure patients receiving bolus injection
Rana Sager1
Isak Lindstedt2
Lars Edvinsson3
Marie-Louise Edvinsson3
1.Department of Emergency and Internal Medicine, Lund University Hospital of Sk(a)ne, Sweden2.Department of Medicine, Institute of Clinical Sciences in Lund, Lund University, Sweden3.Department of Emergency and Internal Medicine, Lund University Hospital of Sk(a)ne, Sweden;Department of Medicine, Institute of Clinical Sciences in Lund, Lund University, Sweden
摘要：Heart failure (HF) is a condition of cardiac dysfunction and fluid overload.Neurohormonal activation via the reninangiotensin-aldosterone system and the sympathetic nervous system are the pathophysiological cornerstones.[1] Furthermore,HF is a disorder widely associated with grave adverse outcomes and poor prognosis.[2] A loop diuretic is the fundamental drug used to prevent multiorgan failure and improve symptoms in these patients.[3] Noteworthy worries have been put forth concerning the risks and benefits of loop diuretics,particularly about the dosage and administration procedure.[4,5] Several observational studies have shown that static drug exposure is associated with increased mortality risk.[6-15] Loop diuretics administered as a continuous infusion have been thought to convey further benefits over bolus injections.
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论文发表日期：2020-06-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 359-364 )
英文信息