Associations of soybean products intake with blood pressure changes and hypertension incidence: the China-PAR project
Jia-Liu WEI1
Xin-Yan WANG1
Fang-Chao LIU1
Ji-Chun CHEN1
Jie CAO1
Jian-Xin LI1
Dong-Sheng HU2
Chong SHEN3
Fang-Hong LU4
Ying-Xin ZHAO4
Jian-Feng HUANG1
Xiang-Feng LU1
1.Key Laboratory of Cardiovascular Epidemiology, Chinese Academy of Medical Sciences, Beijing, China;Department of Epidemiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China2.Department of Prevention Medicine, Shenzhen University School of Medicine, Shenzhen, China;Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, China3.Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China4.Cardio-Cerebrovascular Control and Research Center, Institute of Basic Medicine, Shandong First Medical University, Jinan, Shandong, China
摘要：Background The relationships between dietary intake of soybean products and incident hypertension were still uncertain.This study aimed to illustrate the associations between intake of soybean products with risks of incident hypertension and longitudinal changes of blood pressure in a prospective cohort study.Methods We included 67,499 general Chinese adults from the Project of Prediction for Atherosclerosis Cardiovascular Disease Risk in China (China-PAR).Information about soybean products consumption was collected by standardized questionnaires,and study participants were categorized into the ideal (≥ 125 g/day) or non-ideal (＜ 125 g/day) group.Hazard ratios (HRs) and corresponding 95％ confidence intervals (95％ CIs) for incident hypertension were calculated using Cox proportional hazard models.Among participants with repeated measures of blood pressure,generalized linear models were used to examine the relationships between soybean products consumption and blood pressure changes.Results During a median follow-up of 7.4 years,compared with participants who consumed ＜ 125 g of soybean products per day,multivariable adjusted HR for those in the ideal group was 0.73 (0.67-0.80).This inverse association remained robust across most subgroups while significant interactions were tested between soybean products intake and age,sex,urbanization and geographic region (P values for interaction ＜ 0.05).The mean systolic and diastolic blood pressure levels were 1.05 (0.71-1.39) mmHg and 0.44 (0.22-0.66) mmHg lower among participants in the ideal group than those in the non-ideal group.Conclusions Our study showed that intake of soybean products might reduce the long-term blood pressure levels and hypertension incidence among Chinese population,which has important public health implications for primary prevention of hypertension.
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论文发表日期：2020-07-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 384-392 )
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