Atherosclerosis, its risk factors, and cognitive impairment in older adults
Yun-Li XING1
Michael A Chen2
Ying SUN1
Moni B Neradilek3
Xi-Ting WU1
Dai ZHANG1
Wei HUANG1
Yining CUI1
Qi-Qi YANG1
Hong-Wei LI4
Xue-Qiao ZHAO2
1.Department of Geriatrics and Gerontology, Beijing Friendship Hospital, Capital Medical University, Beijing, China2.Division of Cardiology, University of Washington, Seattle, WA, USA3.The Mountain-Whisper-Light Statistics, Seattle, WA, USA4.Department of Geriatrics and Gerontology, Beijing Friendship Hospital, Capital Medical University, Beijing, China;Cardiovascular Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China
摘要：Objective To examine the association of atherosclerotic cardiovascular disease (ASCVD) and its risk factors with cognitive impairment in older adults.Methods Six hundred and fourteen subjects,aged ≥ 65 years,from one center (2016-2018) underwent clinical,laboratory assessments and the Montreal Cognitive Assessment (MoCA).Using regression analysis,the relationship between ASCVD and its risk factors was evaluated in subjects with and without cognitive impairment (MoCA score ＜ 26).Results Older age (β =-1.3 per 5 years,95％ CI:-1.7 to-0.9,P ＜ 0.001),history of stroke (β =-1.6,95％ CI:-3.0 to-0.3,P =0.01),and myocardial infarction (MI;β =-2.2,95％ CI:-3.6 to-0.8,P =0.003) were independently associated with lower MoCA scores,whereas more education (β =1.5 per 3 years,95％ CI: 1.1 to 1.9,P ＜ 0.001),higher body mass index (BMI;β =0.5 per 3 kg/m2,95％ CI: 0.0 to 1.0,P =0.04),higher estimated glomerular filtration rate (eGFR;β =0.8 per 15 U,95％ CI: 0.1 to 1.4,P =0.03),left ventricular ejection fraction (LVEF;β =0.4 per 5％,95％ CI: 0 to 0.8,P =0.04) and statin use (β =1.3,95％ CI: 0.3 to 2.3,P =0.01) were associated with a higher MoCA score.Cognitive impairment was inde-pendently associated with older age (OR =1.51 per 5 yrs,95％ CI: 1.28 to 1.79,P ＜ 0.001),less education (OR =0.55 per 3 years,95％ CI:0.45 to 0.68,P ＜ 0.001),lower BMI (OR =0.78 per 3 kg/m2,95％ CI: 0.62 to 0.98,P =0.03) and higher levels of high sensitivity c-reactive protein (hsCRP;OR =1.08 per 1 mg/L,95％ CI: 1.02 to 1.15,P =0.01).Conclusions Beyond age,cognitive impairment was associated with prior MI/stroke,higher hsCRP,statin use,less education,lower eGFR,BMI and LVEF.
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论文发表日期：2020-07-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 434-440 )
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