Effects of nicorandil on myocardial infarct size in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: study design and protocol for the randomized controlled trial
Xiao-Si JIANG1
Li-Chao TIAN1
Zi-Chao JIANG2
Yu-Ting ZOU2
Ping LI3
Xin-Chun YANG4
Xi SU5
Jin-Wen TIAN6
Bei SHI7
Zong-Zhuang LI8
Yong-Jun LI9
Ren-Qiang YANG10
Geng QIAN2
Yun-Dai CHEN2
1.Department of Cardiology, the First Medical Center of Chinese PLA General Hospital, Beijing, China;The School of Medicine, Nankai University, Tianjin, China2.Department of Cardiology, the First Medical Center of Chinese PLA General Hospital, Beijing, China3.Department of Cardiology, the First People's Hospital of Yunlin, Guangxi, China4.Department of Cardiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China5.Department of Cardiology, Wuhan Asia Heart Hospital, Wuhan, China6.Department of Cardiology, Hainan Hospital of PLA General Hospital, Hainan, China7.Department of Cardiology, Affiliated Hospital of Zunyi Medical College, Guizhou, China8.Department of Cardiology, Guizhou Provincial People's Hospital, Guizhou, China9.Department of Cardiology, the Second Hospital of Hebei Medical University, Hebei, China10.10Department of Cardiology, the Second Affiliated Hospital of Nanchang University, Jiangxi, China
摘要：Previous studies have shown that nicorandil has a protective effect on cardiomyocytes.However,there is no study to investigate whether perioperative intravenous nicorandil can further reduce the myocardial infarct size in patients with ST-segment elevation myocardial infarction (STEMI) compared to the current standard of percutaneous coronary intervention (PCI) regimen.The CHANGE (China-Administration of Nicorandil Group) study is a multicenter,prospective,randomized,double-blind and parallel-controlled clinical study of STEMI patients undergoing primary PCI in China,aiming to evaluate the efficacy and safety of intravenous nicorandil in ameliorating the myocardial infarct size in STEMI patients undergoing primary PCI and provide evidence-based support for myocardial protection strategies of STEMI patients.
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论文发表日期：2020-08-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 519-524 )
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