Effects and mechanisms of glucose-insulin-potassium on post-procedural myocardial injury after percutaneous coronary intervention
Yi-Dan HAO1
Peng HAO1
Zheng WANG2
Ying-Xin ZHAO1
Zhi-Ming ZHOU1
Yu-Yang LIU1
De-An JIA1
Hong-Ya HAN1
Bin HU1
Hua SHEN1
Fei GAO1
Guo-Zhong PAN3
Zhen-Feng GUO4
Shi-Wei YANG1
Yu-Jie ZHOU1
1.Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Disease, the Key Laboratory of Remodeling-related Cardiovascular Disease, Ministry of Education, Beijing, China2.Peking University Third Hospital, Beijing, China3.Dongzhimen Hospital Eastern Affiliated to Beijing University of Chinese Medicine, Beijing, China4.Benq Medical Center, Nanjing Medical University, Nanjing, China
摘要：Objective To evaluate the effects and mechanisms of glucose-insulin-potassium (GIK) on post-procedural myocardial injury (PMI) after percutaneous coronary intervention (PCI).Methods A total of 200 non-diabetic patients with documented coronary heart disease (CHD) were divided into the Group GIK and Group G,with 100 patients in each group.Patients in Group G were given intravenous infusion of glucose solution 2 hours before PCI.As compared,patients in Group GIK were given GIK.Results Both post-procedural creatine phosphokinase isoenzyme MB (CK-MB;62.1 ± 47.8 vs.48.8 ± 52.6 U/L,P =0.007) and cTnI (0.68 ± 0.83 vs.0.19 ± 0.24 ng/mL,P ＜ 0.001) in Group GIK were significantly higher than those in Group G.In Group G,9.0％ and 4.0％ of patients had post-procedural increases in CK-MB 1-3 times and ＞ 3 times,which were significantly lower than those in Group GIK (14.0％ and 7.0％,respectively;all P values ＜ 0.01);13.0％ and 7.0％ of patients had post-procedural increases in cTnI 1-3 times and ＞ 3 times,which were also significantly lower than those in Group GIK (21.0％ and 13.0％,respectively;all P ＜ 0.001).Pre-procedural (10.2 ± 4.5 vs.5.1 ± 6.3,P ＜ 0.001) and post-procedural rapid blood glucose (RBG) levels (8.9 ± 3.9 vs.5.3 ± 5.6,P ＜ 0.001) in Group G were higher than those in Group GIK.In adjusted logistic models,usage of GIK (compared with glucose solution) remained significantly and independently associated with higher risk of post-procedural increases in both CK-MB and cTnI levels ＞ 3 times.Furthermore,pre-procedural RBG levels ＜ 5.0mmol/L were significantly associated with higher risk of post-procedural increases in both CK-MB and cTnI levels.Conclusions In non-diabetic patients with CHD,the administration of GIK may increase the risk of PMI due to hypoglycemia induced by GIK.
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论文发表日期：2020-09-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 554-560 )
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