Heart failure and left ventricular dysfunction in older patients with chronic kidney disease: the China Hypertension Survey (2012-2015)
Xin WANG
Guang HAO
Lu CHEN
Lin-Feng ZHANG
Zuo CHEN
Yu-Ting KANG
Ying YANG
Cong-Yi ZHENG
Hao-Qi ZHOU
Zeng-Wu WANG
Run-Lin GAO
摘要：Background Heart failure (HF) is a leading cause of hospitalization and mortality for older chronic kidney disease (CKD) patients.However,the epidemiological data is scarce.We aimed to determine the prevalence of left ventricular (LV) dysfunction and HF,and to explore the risk factors for HF among those patients.Methods This is a cross-sectional analysis of the China Hypertension Survey conducted between October 2012 and December 2015.A total of 5,808 participants aged ≥ 65 years were included in the analysis.Self-reported history of HF and any other cardiovascular diseases was acquired.2-D and Doppler echocardiography were used to assess LV dysfunction.CKD was defined as either estimated glomerular filtration rate (eGFR) ＜ 60 mL/min per 1.73 m2 or urinary albumin to creatinine ratio (ACR) ≥ 30 mg/g.Results Among CKD patients aged ≥ 65 years,the weighted prevalence of HF,heart failure with preserved ejection fraction (HFpEF),heart failure with mid-range ejection fraction (HFmrEF),and heart failure with reduced ejection fraction (HFrEF) was 4.8％,2.5％,0.8％,and 1.7％,respectively.The weighted prevalence of HF was 5.0％ in patients with eGFR ＜ 60 mL/min per 1.73 m2,and was 5.9％ in patients with ACR ≥ 30 mg/g.The prevalence of LV systolic dysfunction was 3.1％,and while it was 8.9％ for moderate/severe diastolic dysfunction.Multivariate analysis showed that smoking was significantly associated with the risk of HF.Furthermore,age,smoking,and residents in rural areas were significantly associated with a risk of LV diastolic dysfunction.Conclusions The prevalence of HF and LV dysfunction was high in older patients with CKD,suggesting that particular strategies will be required.
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论文发表日期：2020-10-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 597-603 )
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