Gender differences in clinical outcomes of acute myocardial infarction undergoing percutaneous coronary intervention: insights from the KAMIR-NIH Registry
Myunhee Lee1
Dae-Won Kim1
Mahn-Won Park1
Kyusup Lee1
Kiyuk Chang2
Wook Sung Chung2
Tae Hoon Ahn3
Myung Ho Jeong4
Seung-Woon Rha5
Hyo-Soo Kim6
Hyeon Cheol Gwon6
In Whan Seong7
Kyung Kuk Hwang8
Shung Chull Chae9
Kwon-Bae Kim10
Young Jo Kim11
Kwang Soo Cha12
Seok Kyu Oh13
Jei Keon Chae14
Ji-Hoon Jung15
1.Division of Cardiology, Daejeon St. Mary's hospital, College ofMedicine, The Catholic University ofKorea, Seoul, South Korea2.Division of Cardiology, Seoul St. Mary's hospital, College ofMedicine, The Catholic University ofKorea, Seoul, South Korea3.Gachon University, Gil Medical Center, Incheon, South Korea4.Chonnam National University Hospital, Gwangju, South Korea d Korea University5.Korea University Guro Hospital, Seoul, South Korea6.Seoul National University Hospital, Seoul, South Korea7.Sungkyunkwan Universtiy, Samsung Medical Center, Seoul, South Korea8.Chungnam National University Hospital, Daejeon, South Korea9.Chungbuk National University Hospital, Cheongju, South Korea10.Kyungpook National University Hospital, Daegu, South Korea11.Keimyung University Dongsan Medical Center, Daegu, South Korea12.Yeungnam University Hospital, Daegu, South Korea13.Pusan National University Hospital, Busan, South Korea14.Wonkwang University Hospital, Iksan, South Korea15.Chonbuk National University Hospital, Jeonju, South Korea
摘要：Background There are numerous but conflicting data regarding gender differences in outcomes following percutaneous coronary in?tervention (PCI). Furthermore, gender differences in clinical outcomes with acute myocardial infarction (AMI) following PCI in Asian population remain uncertain because of the under-representation of Asian in previous trials. Methods A total of 13,104 AMI patients from Korea Acute Myocardial Infarction Registry-National Institute of Health (KAMIR-NIH) between November 2011 and December 2015 were classified into male (n = 8021, 75.9％) and female (n = 2547,24.1％). We compared the demographic, clinical and angiographic characteris?tics, 30-days and 1-year major adverse cardiac and cerebrovascular events (MACCE) in women with those in men after AMI by using pro?pensity score (PS) matching. Results Compared with men, women were older, had more comorbidities and more often presented with non-ST segment elevation myocardial infarction (NSTEMI) and reduced left ventricular systolic function. Over the median follow-up of 363 days, gender differences in both 30-days and 1-year MACCE as well as thrombolysis in myocardial infarction minor bleeding risk were not observed in the PS matched population (30-days MACCE: 5.3％ vs. 4.7％, log-rank P = 0.494, HR = 1.126, 95％ CI: 0.800-1.585; 1-year MACCE: 9.3％ vs. 9.0％, log-rank P = 0.803, HR = 1.032,95％ CI: 0.802-1.328; TIMI minor bleeding: 4.9％ vs. 3.9％, log-rank P = 0.215,HR = 1.255, 95％ CI: 0.869-1.814). Conclusions Among Korean AMI population undergoing contemporary PCI, women, as compared with men, had different clinical and angiographic characteristics but showed similar 30-days and 1-year clinical outcomes. The risk of bleed?ing after PCI was comparable between men and women during one-year follow up.
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论文发表日期：2020-11-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：13( 680-688,690-693 )
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