Wild type transthyretin amyloidosis,a reason not to be forgotten for heart failure of preserved ejection fraction in the elderly
Zhuang TIAN1
Chao REN2
Li HUO2
Xiao LI3
Yi-Ning WANG3
Lun HUANG4
Ran TIAN1
Shu-Yang ZHANG1
1.Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China2.Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Meical College, Beijing, China3.Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China4.Department of Cardiology, Jilin Central Hospital, Jilin, China
摘要：Amyloidosis is a multisystem disease that is character-ized by deposition of fibrils in extracellular tissue,which mainly involves the kidney,heart,and autonomic nervous system.Two types of amyloidosis typically infiltrate the heart,including immunoglobulin light-chain(AL)and amyloid transthyretin(ATTR).ATTR is further subdivided into wild-type ATTR and variant ATTR caused by point mutations in the TTR gene.[1]Wild-type ATTR is consid-ered as not uncommon in older patients with heart failure.Recently,a comprehensive set of consensus recommenda-tions for the suspicion and diagnosis of ATTR was pub-lished,with particular focus on the combined application of noninvasive methods.[2]We present here a case of wild-type TTR cardiac amyloidosis(ATTRwt-CA),which was diag-nosed by noninvasive modalities,and provide an overview of the recommended diagnostic approach of CA.Further-more,to the best of our knowledge,this is the first Chinese case of ATTRwt-CA reported to date.
机标关键词：
论文发表日期：2020-12-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 793-796 )
英文信息