Patent foramen ovale closure in non-lacunar cryptogenic ischemic stroke:where are we now?
Adrià ARBOIX1
Olga PARRA2
Josefina ALIÓ3
1.Cerebrovascular Division,Department of Neurology,Hospital Universitari del Sagrat Cor,Universitat de Barcelona,Barcelona,Catalonia,Spain2.Department of Pneumology,Hospital Universitari del Sagrat Cor,Universitat de Barcelona,Barcelona,Catalonia,Spain3.Department of Cardiology,Hospital Universitari de Bellvitge,L'Hospitalet de Llobregat,Barcelona,Catalonia,Spain
摘要：Patent foram ovale(PFO)is the most common anatomical cause of an interarterial shunt.It is usually asympto-matic but may cause paradoxical embolism and is a risk factor for non-lacunar cryptogenic cerebral ischemia in young adults.Al-though the first clinical trials did not show a significant superiority of PFO closure in the secondary prevention of cerebral ischemia as compared with standard antithrombotic treatment,six subsequent randomized clinical trials(CLOSURE I,PC Trial,RESPECT,CLOSE,REDUCE,and DEFENSE-PFO)performed in a sample of cryptogenic stroke in patients aged 60 years or younger provided evidence of a significant reduction of recurrent cerebral ischemia after percutaneous PFO closure.However,the use of percutaneous PFO closure cannot be generalized to the entire population of patients with cerebral ischemia and PFO,but it is indicated in highly selected patients with non-lacunar cryptogenic cerebral infarction with a large right-to-left shunt,an atrial septal aneurysm and no evidence of atrial fibrillation,as well as in association with antithrombotic treatment for an optimal secondary prevention of cerebral ischemia.
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论文发表日期：2021-01-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 67-74 )