Incidence, predictors, and prognosis of thrombocytopenia among patients undergoing intra-aortic balloon pumping in the intensive care unit: a propensity score analysis
Wei TONG1
Jun-Mei WANG2
Jia-Yue LI1
Pei-Yao LI3
Yun-Dai CHEN1
Zheng-Bo ZHANG4
Wei DONG1
1.Department of Cardiology, the Sixth Medical Centre, Chinese PLA General Hospital, Beijing, China2.Center for Artificial Intelligence in Medicine, Chinese PLA General Hospital, Beijing, China;CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, China National Center for Bioinformation, Beijing, China3.Center for Artificial Intelligence in Medicine, Chinese PLA General Hospital, Beijing, China;Global Health Drug Discovery Institute, Beijing, China4.Center for Artificial Intelligence in Medicine, Chinese PLA General Hospital, Beijing, China
摘要：OBJECTIVE To explore the incidence,predictors,and prognosis of intra-aortic balloon pumping (IABP)-related thrombocytopenia in critically ill patients.METHODS This multi-center study used the eICU Collaborative Research Database V1.2,comprising data on ＞ 130,000 patients from multiple intensive care units (ICUs) in America between 2014 and 2015.A total of 710 patients undergoing IABP were included.Thrombocytopenia was defined as a drop in platelet count ＞ 50％ from baseline.From the cohort,167 patients who developed thrombocytopenia were matched 1∶1 with 167 patients who did not,after propensity score (PS) matching.The associations between IABP-related thrombocytopenia and clinical outcomes were examined by multivariable logistic regression.RESULTS Among 710 patients undergoing IABP,249 patients (35.07％) developed thrombocytopenia.The APACHE Wa score was a predictor of thrombocytopenia[adjusted odds ratio (OR) =1.09,95％ confidence interval (CO: 1.02-1.15].After 1∶1 PS matching,in-hospital mortality (adjusted OR =0.76,95％ CI: 0.37-1.56) and in-ICU mortality (adjusted OR =0.74,95％ CI: 0.34-1.63) were similar between the thrombocytopenia and non-thrombocytopenia groups.However,major bleeding occurred more frequently in the thrombocytopenia group (adjusted OR =2.54,95％ CI: 1.54-4.17).In-hospital length of stay (LOS) and inICU LOS were significantly longer in patients who developed thrombocytopenia than in those who did not (9.71 vs.7.36,P ＜ 0.001;5.13 vs.2.83,P＜ 0.001).CONCLUSIONS Among patients undergoing IABP in the ICUs,thrombocytopenia was not associated with a difference in inhospital mortality or in-ICU mortality;however,thrombocytopenia was significantly associated with a greater risk of major bleeding and increased in-ICU and in-hospital LOS.
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论文发表日期：2021-02-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：12( 123-134 )