Effects of the total physical activity and its changes on incidence,progression,and remission of hypertension
Can CAI1
Fang-Chao LIU2
Jian-Xin LI2
Ke-Yong HUANG2
Xue-Li YANG3
Ji-Chun CHEN2
Xiao-Qing LIU4
Jie CAO2
Shu-Feng CHEN2
Chong SHEN5
Ling YU6
Fang-Hong LU7
Xian-Ping WU8
Lian-Cheng ZHAO2
Ying LI2
Dong-Sheng HU9
Jian-Feng HUANG2
Xiao-Yang ZHOU10
Xiang-Feng LU2
Dong-Feng GU2
1.Department of Cardiology,Renmin Hospital of Wuhan University,Wuhan 430060,China;Key Laboratory of Cardiovascular Epidemiology&Department of Epidemiology,Fuwai Hospital,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100037,China2.Key Laboratory of Cardiovascular Epidemiology&Department of Epidemiology,Fuwai Hospital,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100037,China3.Tianjin Key Laboratory of Environment,Nutrition and Public Health,Department of Occupational and Environmental Health,School of Public Health,Tianjin Medical University,Tianjin 300070,China4.Division of Epidemiology,Guangdong Provincial People's Hospital and Cardiovascular Institute,Guangzhou 510080,China5.Department of Epidemiology and Biostatistics,School of Public Health,Nanjing Medical University,Nanjing 211166,China6.Department of Cardiology,Fujian Provincial Hospital,Fuzhou 350014,China7.Cardio-Cerebrovascular Control and Research Center,Institute of Basic Medicine,Shandong Academy of Medical Sciences,Jinan 250062,China8.Sichuan Center for Disease Control and Prevention,Chengdu 610041,China9.Department of Epidemiology and Health Statistics,School of Public Health,Shenzhen University Health Science Center,Shenzhen 518060,China10.Department of Cardiology,Renmin Hospital of Wuhan University,Wuhan 430060,China
摘要：OBJECTIVES Moderate to vigorous physical activity is recommended to prevent hypertension according to the current guidelines.However,the degree to which the total physical activity(TPA)and its changes benefit normotensives and hypertens-ives is uncertain.We aimed to examine the effects of TPA and its changes on the incidence,progression,and remission of hyper-tension in the large-scale prospective cohorts.METHODS A total of 73,077 participants(55,101 normotensives and 17,976 hypertensives)were eligible for TPA analyses.Dur-ing a mean follow-up of 7.16 years(394,038 person-years),12,211 hypertension cases were identified.TPA was estimated as meta-bolic equivalents and categorized into quartiles.Cox proportional hazards regression and multivariable logistic regression were used to estimate associations of TPA and changes in TPA with incident hypertension and progression/remission of hypertension.RESULTS Compared with the lowest quartile of TPA,normotensives at the third and the highest quartile had a decreased risk of incident hypertension,with hazard ratios(HRs)of 0.86[95％confidence interval(CI):0.81-0.91]and 0.81(95％CI:0.77-0.86),respectively.Hypertensives at the highest quartile of TPA demonstrated a decreased risk of progression of hypertension[odds ra-tio(OR)= 0.87,95％CI:0.79-0.95],and an increased probability of hypertension remission(OR = 1.17,95％CI:1.05-1.29).Moreover,getting active from a sedentary lifestyle during the follow-up period could reduce 25％(HR = 0.75,95％Cl:0.58-0.96)risk of incident hypertension,whereas those becoming sedentary did not achieve benefit from initially being active.CONCLUSIONS Our findings indicated that increasing and maintaining TPA levels could benefit normotensives,whereas higher TPA levels were needed to effectively control progression and improve remission of hypertension.Physical activity played undoubtedly an essential role in both primary and secondary prevention of hypertension.
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论文发表日期：2021-03-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 175-184 )