Association of changes in waist circumference with cardiovascular disease and all-cause mortality among the elderly Chinese population:a retrospective cohort study
Xue-Ning ZHANG1
Hao ZHAO1
Zhan SHI2
Ling YIN3
Xiao-Yan ZHAO3
Chun-Yu YIN3
Yong-Li YANG1
Song-He SHI1
1.Department of Epidemiology and Biostatistics,College of Public Health,Zhengzhou University,Zhengzhou,Henan,China2.Department of Pharmacy,Zhengzhou First People's Hospital,Zhengzhou,Henan,China3.Department of Neurology,Chinese People's Liberation Army General Hospital,Beijing,China
摘要：BACKGROUND To examine the association of baseline waist circumference(WC)and changes in WC with cardiovascular dis-ease(CVD)and all-cause mortality among elderly people.METHODS A total of 30,041 eligible participants were included from a retrospective cohort in China.The same questionnaire,anthropometric and laboratory measurements were performed at baseline(2010)and the first follow-up(2013).The percent change in WC between baseline and the first follow-up was calculated to evaluate three years change of WC.We collected the oc-currence of CVD and all-cause death from the first follow-up to December 31,2018.Restricted cubic splines and Cox proportional-hazards regression models were used to evaluate the relationship between baseline WC/changes in WC and mortality.RESULTS The dose-response relationships between baseline WC and CVD mortality were U-or J-shaped.In low WC group,compared with stable group,the fully adjusted hazard ratio(aHR)for CVD mortality was 1.60(95％CI:1.24-2.06)in WC gain group among men.In normal WC group,the CVD mortality risk increased with WC gain(men:aHR = 1.86,95％CI:1.36-2.56;women:aHR = 1.83,95％CI:1.29-2.58).In moderate-high WC group,the CVD mortality risk increased with WC gain(men:aHR =1.76,95％CI:1.08-2.88;women:aHR = 1.46,95％CI:1.04-2.05)and risk decreased with WC loss(men:aHR = 0.54,95％CI:0.30-0.98;women:aHR = 0.59,95％CI:0.37-0.96).CONCLUSIONS For the elderly population,WC gain may increase CVD mortality risk regardless of baseline WC,whereas WC reduction could decrease the risk only in the moderate-high WC group.
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论文发表日期：2021-03-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：11( 185-195 )