Factors associated with change in frailty scores and long-term outcomes in older adults with coronary artery disease
S.Michael Gharacholou1
Joshua P.Slusser2
Ryan J.Lennon2
Carolyn R.Flock3
Leslie T.Cooper4
Patricia A.Pellikka5
Jorge Brenes Salazar5
Mandeep Singh5
1.Department of Cardiovascular Medicine,Mayo Clinic,Jacksonville,FL,USA;Department of Cardiology,Mayo Health System,La Crosse,WI,USA2.Department of Biostatistics,Mayo Clinic,Rochester,MN,USA3.Department of Cardiology,Mayo Health System,La Crosse,WI,USA4.Department of Cardiovascular Medicine,Mayo Clinic,Jacksonville,FL,USA5.Department of Cardiovascular Medicine,Mayo Clinic,Rochester,MN,USA
摘要：OBJECTIVE Older adults with coronary artery disease(CAD)are at risk for frailty.However,little is known regarding trans-ition in frailty measures over time or its impact on outcomes.We sought to determine the association of temporal change in frailty with long-term outcome in older adults with CAD.METHODS We re-assessed for phenotypic frailty using the Fried index(0 = not frail;1-2 = pre-frail;≥3 frail)in a cohort of CAD patients≥65 years old at 2 time points 5 years apart.Factors associated with frailty worsening were assessed with scatter-plots and outcomes estimated using the Kaplan-Meier method.Cox models were used to assess the risk of worsening frailty on outcome.RESULTS There were 45 subjects that completed both baseline and 5-year Fried frailty assessment.Mean age was 74.6±5.9 and 30(67％)were men.Frailty incidence increased over time:baseline(3％frail,37％pre-frail);5 years(10％frail,40％pre-frail).Baseline factors were not predictors of worsening frailty score,while both slower walk time(r = 0.46;P = 0.004)and diminishing grip strength(r =-0.39;P = 0.01)were associated with worsening frailty transitions.In follow-up(median 5.2 years),long-term major adverse cardiac event(MACE)free survival(P = 0.12)or hospitalization(P = 0.98)was not different for those with worsen-ing frailty score(referent:improved/unchanged frailty).Frailty worsening had a trend towards increased risk of MACE(HR =1.86;95％CI:0.65-5.27,P= 0.25).CONCLUSIONS Frailty transitions,specifically,declines in walk time and grip strength,were strongly associated with worsening frailty score in a cohort of older adults with CAD than were baseline indices,though frailty change status was not in-dependently associated with MACE outcomes.
机标关键词：
论文发表日期：2021-03-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 196-203 )