Calculation of left ventricular diastolic time constant (Tau) in dogs with aortic regurgitation using continuous-wave Doppler spectra
Chun-Zhi FAN1
Jing SUN2
Hai-Ning ZHENG3
Chao-Yang WEN3
1.Department of Ultrasound, Peking University International Hospital, Beijing, China;Department of Ultrasound, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China2.Department of Ultrasound, Peking University International Hospital, Beijing, China;Cardiovascular Department, Shannxi Province Crops Hospital of Chinese People's Armed Police Forces, Xi'an, China3.Department of Ultrasound, Peking University International Hospital, Beijing, China
摘要：OBJECTIVE To investigate a new noninvasive method for calculating left ventricular diastolic time constant (Tau) through a continuous-wave aortic regurgitation Doppler spectrum.METHODS According to ultrasound guidance,twenty-four animal models (beagles) of aortic regurgitation and acute ischemic lefdt ventricular diastolic dysfunction were created.The left ventricular diastolic function was manipulated with dobutamine or esmolol and fifty-nine hemodynamic stages were achieved.Raw audio signals of the continuous-wave Doppler spectra were collected,and new aortic regurgitation Doppler spectra were built after reprocessing by a personal computer.The updating time of the spectral line was 0.3 ms.The new Doppler spectra contour line was automated using MATLAB (MATrix LABoratory,MathWorks,Natick,MA,USA),and two time intervals,(t2-t1) and (t3-t1) were measured on the ascending branch of the aortic regurgitation Doppler spectrum.Then,the two time intervals were substituted into Bai's equations,and Doppler-derived Tan (Tau-D) was resolved and compared with catheter-derived Tau (Tau-c).RESULTS There is no significant difference between Tau-D and Tau-c (45.95 ± 16.90 ms and 46.81 ± 17.31 ms,respectively;P＞ 0.05).Correlation analysis between Tau-c and Tau-D suggested a strong positive relationship (r=0.97,P=0.000).A Bland-Altman plot of Tau-c and Tau-D revealed fair agreement.CONCLUSIONS This new calculation method is simple,convenient,and shows a strong positive relationship and fair agreement with the catheter method.
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论文发表日期：2021-04-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 252-260 )