The impact of post-operative atrial fibrillation on outcomes in coronary artery bypass graft and combined procedures
Yau-Lam Alex Chau1
Ji Won Yoo1
Ho Chuen Yuen2
Khalid Bin Waleed3
Dong Chang4
Tong Liu5
Fang Zhou Liu6
Gary Tse7
Sharen Lee8
Ka Hou Christien Li9
1.Faculty of Pharmaceutical Sciences,University of British Columbia,British Columbia,Canada2.Department of Medicine and Geriatrics,Princess Margaret Hospital,Hong Kong,China3.Department of Cardiology,Fuwai Hospital Chinese Academy of Medical Sciences Shenzhen,Shenzhen,China;Institute of Biomedicine and Biotechnology,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen,China4.Xiamen Cardiovascular Hospital,Xiamen University,Xiamen,China5.Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease,Department of Cardiology,Tianjin Institute of Cardiology,The Second Hospital of Tianjin Medical University,Tianjin,China6.Department of Cardiology,Guangdong Cardiovascular Institute,Guangdong Provincial People's Hospital,Guangdong Academy of Medical Sciences,Guangzhou,China7.Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease,Department of Cardiology,Tianjin Institute of Cardiology,The Second Hospital of Tianjin Medical University,Tianjin,China;Faculty of Health and Medical Sciences,University of Surrey,GU27AL,Guildford,United Kingdom8.Cardiovascular Analytics Group,Laboratory of Cardiovascular Physiology,Hong Kong,China9.Arrowe Park Acute Stroke Unit,Wirral University Teaching Hospital NHS Foundation Trust,Wirral,UK
摘要：BACKGROUND Post-operative atrial fibrillation (POAF) is a common yet understudied clinical issue after coronary artery by-pass graft (CABG) leading to higher mortality rates and stroke.This systematic review and meta-analysis evaluated the rates of adverse outcomes between patients with and without POAF in patients treated with CABG or combined procedures.METHODS The search period was from the beginning of PubMed and Embase to May 18th,2020 with no language restrictions.The inclusion criteria were:(1) studies comparing new onset atrial fibrillation before or after revascularization vs.no new onset AF before or after revascularization.The outcomes assessed included all-cause mortality,cardiac death,cerebral vascular acci-dent (CVA),myocardial infarction (MI),repeated revascularization,major adverse cardiac event (MACE),and major adverse car-diac and cerebrovascular events (MACCEs).RESULTS Of the 7,279 entries screened,11 studies comprising of 57,384 patients were included.Compared to non-POAF,POAF was significantly associated with higher risk of all-cause mortality (Risk Ratio (RR) =1.58;95％ Confidence Interval (CI):1.42-1.76,P ＜ 0.00001) with accompanying high level of heterogeneity (I2 =62％).Conclusions Patients with POAF after CABG or combined procedures are at an increased risk of all-cause mortality or CVAs.Therefore,POAF after such procedures should be closely monitored and treated judiciously to minimize risk of further complica-tions.While there are studies on POAF versus no POAF on outcomes,the heterogeneity suggests that further studies are needed.
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论文发表日期：2021-05-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 319-326 )