Potentially inappropriate prescribing of cardiovascular system and antiplatelet/anticoagulant drugs among elderly patients:a Korean population-based national study
Jongyeon Kim1
Euna Han2
Hee-Jin Hwang3
Hyeonseok Cho2
Young-Sang Kim4
Hyejin Chun4
Jinkwon Kim5
Yon Chul Park6
Hye-Young Kang2
1.Department of Pharmaceutical Medicine and Regulatory Sciences,Colleges of Medicine and Pharmacy,Yonsei University,Incheon,South Korea2.College of Pharmacy,Yonsei Institute of Pharmaceutical Sciences,Yonsei University,Incheon,South Korea3.Department of Family Medicine,Catholic Kwandong University International St.Mary's Hospital,Incheon,South Korea4.Department of Family Medicine,CHA Bundang Medical Center,CHA University,Seongnam,South Korea5.Department of Neurology,Yongin Severance Hospital,Yonsei University College of Medicine,Yongin,South Korea6.Department of Family Medicine,Wonju Severance Christian Hospital,Wonju,South Korea
摘要：OBJECTIVES To investigate the prevalence of potentially inappropriate prescribing (PIP) for cardiovascular system (CVS) and antiplatelet/anticoagulant (AP/AC) drugs among Korean elderly patients,using the Screening Tool of Older Persons' Prescrip-tions (STOPP) criteria version 2 and to identify the risk factors related to PIP.METHODS The 2016 National Aged Patient Sample data,comprising National Health Insurance claim records for a random sample of 20％ of patients aged ≥ 65 years,were used to calculate PIP prevalence of outpatient prescriptions.For criteria includ-ing drug-disease interactions,PIP prevalence per indication was estimated.RESULTS Among 1,274,148 elderly patients and 27,062,307 outpatient prescription claims,100,085 patients (7.85％) and 341,664 claims (1.27％) had one or more PIP.The most frequent PIP was "non-steroidal anti-inflammatory drug with concurrent antiplate-let agent (s) without proton-pump inhibitor prophylaxis" in the claim-level (0.97％) and patient-level (6.33％) analyses."Beta-blocker with bradycardia" (16.47％ of claims) and "angiotensin receptor blockers in patients with hyperkalaemia" (23.89％ of claims) showed the highest PIP prevalence per indication.Logistic regression analysis revealed that,among the patient and health care provider characteristics,female,older age,more severe comorbidities,polypharmacy,higher level of healthcare or-ganization,and specialty of prescriber were significantly associated with a higher risk of PIP.CONCLUSIONS Our findings of a high prevalence of PIP for CVS and AP/AC drugs among the elderly suggest that an effect-ive strategy is urgently needed to improve the prescription practices of these drugs.
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论文发表日期：2021-05-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：11( 327-337 )