Beta-blocker treatment in heart failure patients with atrial fibrillation:challenges and perspectives
Emmanouil Chourdakis1
Ioanna Koniari2
Dimitrios Velissaris3
Grigorios Tsigkas4
Nikolaos G Kounis4
Neriman Osman1
1.Krankenhaus der Barmherzigen Brüder Trier,Germany2.Manchester Heart Institute,Manchester University Foundation Trust,Manchester,United Kingdom3.Department of Internal Medicine,University Hospital of Patras,Patras,Greece4.Cardiology Department,University Hospital of Patras,Patras,Greece
摘要：Heart failure (HF) and atrial fibrillation (AF) are common conditions that share similar clinical phenotype and frequently coexist.The classification of HF in patients with preserved ejection fraction (＞ 50％,HFpEF),mid-range reduced EF(40％-49％,HFmrEF) and reduced EF (＜ 40％,HFrEF) are crucial for optimising the therapeutic approach,as each subgroup re-sponds differently.Beta-blocker constitute an important component of our pharmacological regimen for chronic HF.Beta-blocker administration is reccomended in patients with HF with reduced ejection fraction in stable sinus rhythm,due to improvement of symptoms,the better long term-outcome and survival.The beneficial role of beta-blocker use in patients with preserved EF still remain unclear,as no treatment showed a positive impact,regarding morbidity or mortality reduction.The presence of AF in HF patients increases as the disease severity evolves and is associated with a higher rate of cardiovascular morbidity and mortality.But more question is the use of betablocker in HF patients irrespective of EF and concomitant AF.There are many conflicting data and publications,regarding the beta blocker benefit in this population.Generally,it is supported an attenuation of beta-blockers beneficial effect in HF patients with AF.A design of more randomised trials/studies with HF patients and concomitant AF may improve our clinical approach of beta-blockers use and identify the patients with HF,who mostly profit from an invasive ap-proach.
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论文发表日期：2021-05-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：14( 362-375 )