Vulnerable atherosclerotic plaque features:findings from coronary imaging
Osamu Kurihara1
Masamichi Takano1
Yasushi Miyauchi1
Kyoichi Mizuno2
Wataru Shimizu3
1.Cardiovascular Center,Chiba Hokusoh Hospital,Nippon Medical School,Chiba,Japan2.Mitsukoshi Health and Welfare Foundation,Tokyo,Japan3.Division of Cardiology,Nippon Medical School,Tokyo,Japan
摘要：Pathological studies have suggested that features of vulnerable atherosclerotic plaques likely to progress and lead to acute cardiovascular events have specific characteristics.Given the progress of intravascular coronary imaging techno-logy,some large prospective studies have detected features of vulnerable atherosclerotic plaques using these imaging modalities.However,the rate of cardiovascular events,such as acute coronary syndrome,has been found to be considerably reduced in the limited follow-up period available in the statin era.Additionally,not all disrupted plaques lead to thrombus formation with clin-ical presentation.If sub-occlusive or occlusive thrombus formation does not occur,a thrombus on a disrupted plaque will organ-ize without any symptoms,forming a "healed plaque".Although vulnerable plaque detection using intracoronary imaging is fo-cused on "thin-cap fibroatheroma" leading to plaque rupture,superficial plaque erosion is increasingly recognized;however,the underlying mechanism of thrombus formation on eroded plaques is not well understood.One of intravascular imaging,optical coherence tomography (OCT) has the highest image resolution and has enabled detailed characterization of the plaquein vivo.Here,we reviewed the status and limitations of intravascular imaging in terms of detecting vulnerable plaque through mainly OCT studies.We suggested that vulnerable plaque should be reconsidered in terms of eroded plaque and healed plaque and that both plaque and circulating blood should be assessed in greater detail accordingly.
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论文发表日期：2021-07-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 577-584 )