Impact of statin intensity on adverse cardiac and cerebrovascular events in older adult patients with myocardial infarction
In Tae Moon1
Si-Hyuck Kang2
Wonjae Lee2
Youngjin Cho2
Jin Joo Park2
Yeonyee E.Yoon2
Il-Young Oh2
Chang-Hwan Yoon2
Jung-Won Suh2
Tae-Jin Youn2
In-Ho Chae2
Dong-Ju Choi2
Young-Seok Cho3
1.Uijeongbu Eulji Medical Center,Eulji University School of Medicine,Uijeongbu,South Korea2.Seoul National University Bundang Hospital,Seongnam,South Korea3.Department of Cardiology,Incheon Sejong Hospital,Incheon,South Korea
摘要：BACKGROUND There is insufficient evidence regarding the effect of high-intensity statin therapy in older adults.This study aimed to investigate the effects of high-intensity statin treatment on the clinical outcomes in older adults with myocardial infarc-tion (MI).METHODS Consecutive patients with MI aged at least 75 years were analyzed retrospectively.The primary endpoint was major adverse cardiac and cerebrovascular events (MACCE),defined as a composite of all-cause death,MI,rehospitalization due to un-stable angina,repeat revascularization,and ischemic stroke.The high-intensity group was compared to the low-to-moderate in-tensity group in the propensity score-matched cohort.RESULTS Average age of total 546 patients was 81 years.Among them,84％ of patients underwent percutaneous coronary in-tervention.The unadjusted seven-year MACCE rate differed by statin intensity (high-intensity statin group:38％,moderate-intensity statin group:42％,low-intensity statin group:56％,and no-statin group:61％,P =0.004).However,among these groups,many baseline characteristics were significantly different.Among the 74 propensity score-matched pairs,which lacked any significant differences in all baseline characteristics,the high-intensity group had a significantly lower rate of MACCE than the low-to-moderate intensity group (37％ vs.53％,P =0.047).Follow-up low-density lipoprotein cholesterol levels were significantly lower in the high-intensity group than that in the low-to-moderate intensity group (69.4 ± 16.0 mg/dL vs.77.9 ± 25.9 mg/dL,P=0.026).CONCLUSIONS In older adult patients with MI,the use of high-intensity statin caused significantly less occurrence of MACCE in comparison to that in low-to-moderate intensity for up to seven years of follow-up.
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论文发表日期：2021-08-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：14( 609-622 )