Prognostic relevance of normocytic anemia in elderly patients affected by cardiovascular disease
Liana Spazzafumo1
Fabiola Olivieri2
Jacopo Sabbatinelli3
Roberta Galeazzi4
Rina Recchioni5
Fiorella Marcheselli5
Paola Tamburrini6
Roberto Antonicelli6
1.Epidemiologic Observatory,Regional Health Agency,Regione Marche,Ancona,Italy2.Department of Clinical and Molecular Sciences,Università Politecnica delle Marche,Ancona,Italy;Center of Clinical Pathology and Innovative Therapy,Italian National Research Centre on Aging,IRCCS INRCA,Ancona,Italy3.Department of Clinical and Molecular Sciences,Università Politecnica delle Marche,Ancona,Italy;SOD Medicina di Laboratorio,Azienda Ospedaliero Universitaria Ospedali Riuniti,Ancona,Italy4.Clinical Laboratory and Molecular Diagnostic,Italian National Research Center on Aging,IRCCS INRCA,Ancona,Italy5.Center of Clinical Pathology and Innovative Therapy,Italian National Research Centre on Aging,IRCCS INRCA,Ancona,Italy6.Department of Cardiology-CCU,Italian National Research Centre on Aging,IRCCS INRCA,Ancona,Italy
摘要：BACKGROUND Anemia associated with cardiovascular diseases (CVD) is a common condition in older persons.Prevalence and prognostic role of anemia were extensively studied in patients with myocardial infarction (MI) or congestive heart failure(CHF) whereas limited data were available on patients with atrial fibrillation (AF).This study was conducted to assess the clinical prevalence and prognostic relevance of anemia in elderly patients affected by AF and other CVDs.METHODS A total of 866 elderly patients (430 men and 436 women,age:65-98 years,mean age:85 ± 10 years) were enrolled.Among these patients,267 patients had acute non-ST-segment elevation MI (NSTEMI),176 patients had acute CHF,194 patients had acute AF and 229 patients were aged-matched healthy persons (CTR).All parameters were measured at the hospital admis-sion and cardiovascular mortality was assessed during twenty-four months of follow-up.RESULTS The prevalence of anemia was higher in NSTEMI,CHF and AF patients compared to CTR subjects (50％ vs.15％,P ＜0.05),with normocytic anemia being the most prevalent type (90％).Adjusted mortality risk was higher in anemic patient versus non-anemic patient in all the groups of patients[NSTEMI:hazard ratio (HR) =1.81,95％ CI:1.06-2.13;CHF:HR =2.49,95％ CI:1.31-4.75;AF:HR =1.98,95％ CI:1.01-3.88].Decreased hemoglobin levels (P =0.001) and high reticulocyte index (P =0.023) were associated with higher mortality in CVD patients.CONCLUSIONS The significant associations between CVD and anemia and the prognostic relevance of anemia for elderly pa-tients with CVD were confirmed in this study.The presence of anemia in AF patients is associated with a two-fold increased mor-tality risk compared with non-anemic AF patients.Low hemoglobin and high reticulocyte count independently predict mortality in elderly patients with CVD.
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论文发表日期：2021-08-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 654-662 )