Atypical antipsychotics and oxidative cardiotoxicity:review of literature and future perspectives to prevent sudden cardiac death
Stefano D'Errico1
Raffaele La Russa2
Aniello Maiese3
Alessandro Santurro4
Matteo Scopetti4
Silvia Romano4
Martina Zanon1
Paola Frati5
Vittorio Fineschi5
1.Department of Medical,Surgical and Health Sciences,University of Trieste,Trieste,Italy2.Department of Clinical and Experimental Medicine,University of Foggia,Foggia,Italy;IRCSS Neuromed Mediterranean Neurological Institute,Pozzilli,Italy3.IRCSS Neuromed Mediterranean Neurological Institute,Pozzilli,Italy;Department of Surgical Pathology,Medical,Molecular and Critical Area,University of Pisa,Pisa,Italy4.Department of Anatomical,Histological,Forensic and Orthopaedic Sciences,Sapienza University of Rome,Rome,Italy5.IRCSS Neuromed Mediterranean Neurological Institute,Pozzilli,Italy;Department of Anatomical,Histological,Forensic and Orthopaedic Sciences,Sapienza University of Rome,Rome,Italy
摘要：Oxidative stress is considered the principal mediator of myocardial injury under pathological conditions.It is well known that reactive oxygen (ROS) or nitrogen species (RNS) are involved in myocardial injury and repair at the same time and that cellular damage is generally due to an unbalance between generation and elimination of the free radicals due to an inad-equate mechanism of antioxidant defense or to an increase in ROS and RNS.Major adverse cardiovascular events are often asso-ciated with drugs with associated findings such as fibrosis or inflammation of the myocardium.Despite efforts in the preclinical phase of the development of drugs,cardiotoxicity still remains a great concern.Cardiac toxicity due to second-generation anti-psychotics (clozapine,olanzapine,quetiapine) has been observed in preclinical studies and described in patients affected with mental disorders.A role of oxidative stress has been hypothesized but more evidence is needed to confirm a causal relationship.A better knowledge of cardiotoxicity mechanisms should address in the future to establish the right dose and length of treatment without impacting the physical health of the patients.
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论文发表日期：2021-08-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：23( 663-685 )