Inflammatory abdominal aortic aneurysms treated with leflunomide:an eight-year follow-up case report and literature review
Xue-Ping WU1
Xiao-Ning ZHAO1
Xiao-Qun ZHU2
Wei-Ren CHEN1
1.Department of Cardiology,the Second Medical Center,National Clinical Research Center of Geriatric Disease,Chinese PLA General Hospital,Beijing,China2.Respiration Medicine,the Second Medical Center,National Clinical Research Center of Geriatric Disease,Chinese PLA General Hospital,Beijing,China
摘要：The inflammatory abdominal aortic an-eurysm(IAAA)is an uncommon variant of aortic aneurysm and represents between 3％and 10％of all abdominal aortic aneurysms(AAA).[1]The pathogenesis and clinical manifesta-tions of IAAA differ from those of AAA,and IAAA can easily be misdiagnosed due to varied clinical symptoms of multiple organs inflammation.IAAA is often complicated with obstructive uropathy which needs to be treated with ureteric stenting,[2]principles of IAAA aim at prevention of aortic rup-ture and include open-surgical or endovascular therapies.However,open repair of IAAA is challen-ging and carries a higher perioperative risk,early morbidity,long-term infection rate even in high-volume centers.[3,4]Since pathogenesis of IAAA is now considered to represent aortic lesions of im-munoglobulin G4(IgG4)-related systemic disease,[5,6]and an IAAA case was reported that it was treated with steroid without surgery.[7]Herein,we present an eight-year follow-up case of IAAA in common iliac arteries successfully treated with leflunomide following steroid therapy to avoid ureteric stenting and delay aortic aneurysm surgery.To be best of our knowledge,this is the first case of IAAA treated with leflunomide as a maintenance treatment.
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论文发表日期：2021-10-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 847-850 )