Blood lead level in Chinese adults with and without coronary artery disease
Shi-Hong LI1
Hong-Ju ZHANG2
Xiao-Dong LI3
Jian CUI3
Yu-Tong CHENG1
Qian WANG1
Su WANG1
Chayakrit Krittanawong4
Edward A El-Am5
Rody G.Bou Chaaya5
Xiang-Yu WU1
Wei GU1
Hong-Hong LIU1
Xian-Liang YAN1
Zhi-Zhong LI1
Shi-Wei YANG1
Tao SUN1
1.Department of Cardiology,Beijing Anzhen Hospital,Capital Medical University,Beijing,China2.Department of Echocardiography,Beijing Children's Hospital,Capital Medical University,National Center for Children's Health,Beijing,China3.Department of Cardiology,Shougang Changzhi Steel Hospital,Changzhi,China4.Department of Cardiology,Baylor College of Medicine,Houston,USA5.Department of Medicine,Indiana University School of Medicine,Indianapolis,USA
摘要：BACKGROUND The Trial to Assess Chelation Therapy study found that edetate disodium (disodium ethylenediaminetet-raacetic acid) chelation therapy significantly reduced the incidence of cardiac events in stable post-myocardial infarction patients, and a body of epidemiological data has shown that accumulation of biologically active metals, such as lead and cadmium, is an important risk factor for cardiovascular disease. However, limited studies have focused on the relationship between angiograph-ically diagnosed coronary artery disease (CAD) and lead exposure. This study compared blood lead level (BLL) in Chinese pa-tients with and without CAD.METHODS In this prospective, observational study, 450 consecutive patients admitted to Beijing Anzhen Hospital with sus-pected CAD from November 1, 2018, to January 30, 2019, were enrolled. All patients underwent coronary angiography, and an experienced heart team calculated the SYNTAX scores (SXscore) for all available coronary angiograms. BLLs were determined with atomic absorption spectrophotometry and compared between patients with angiographically diagnosed CAD and those without CAD. RESULTS In total, 343 (76％) patients had CAD, of whom 42％ had low (0?22), 22％ had intermediate (23?32), and 36％ had high (≥ 33) SXscore. BLLs were 36.8 ± 16.95 μg/L in patients with CAD and 31.2 ± 15.75 μg/L in those without CAD (P = 0.003). When BLLs were categorized into three groups (low, middle, high), CAD prevalence increased with increasing BLLs (P < 0.05). In the multivariate regression model, BLLs were associated with CAD (odds ratio (OR): 1.023, 95％ confidence interval (CI): 1.008?1.039;P = 0.0017). OR in the high versus low BLL group was 2.36 (95％ CI: 1.29?4.42, P = 0.003). Furthermore, BLLs were independently associated with intermediate and high SXscore (adjusted OR: 1.050, 95％ CI: 1.036–1.066; P < 0.0001).CONCLUSION BLLs were significantly associated with angiographically diagnosed CAD. Furthermore, BLLs showed excel-lent predictive value for SXscore, especially for complex coronary artery lesions.
机标关键词：chineselevelbloodleadadultsarterycoronarydisease
论文发表日期：2021-11-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 857-866 )