Biomarkers in the clinical management of patients with atrial fibrillation and heart failure
Ioanna Koniari1
Eleni Artopoulou2
Dimitrios Velissaris2
Mark Ainslie3
Virginia Mplani4
Georgia Karavasili1
Nicholas Kounis4
Grigorios Tsigkas4
1.Manchester Heart Institute, Manchester University Foundation Trust, Manchester, United Kingdom2.Department of Internal Medicine, University Hospital of Patras, Patras, Greece3.Manchester Heart Institute, Manchester University Foundation Trust, Manchester, United Kingdom;Division of Cardiovascular Sciences, University of Manchester4.Department of Cardiology, University Hospital of Patras, Patras, Greece
摘要：Atrial fibrillation (AF) and heart failure (HF) are two cardiovascular diseases with an increasing prevalence worldwide. These conditions share common pathophysiologiesand frequently co-exit. In fact, the occurrence of either condition can 'cause ' the development of the other, creating a new patient group that demands different management strategies to that if they occur in isolation. Regardless of the temproral association of the two conditions, their presence is linked with adverse cardi-ovascular outcomes, increased rate of hospitalizations, and increased economic burden on healthcare systems. The use of low-cost, easily accessible and applicable biomarkers may hasten the correct diagnosis and the effective treatment of AF and HF. Both AF and HF effect multiple physiological pathways and thus a great number of biomarkers can be measured that potentially give the clinician important diagnostic and prognostic information. These will then guide patient centred therapeutic management. The current biomarkers that offer potential for guiding therapy, focus on the physiological pathways of miRNA, myocardial stretch and injury, oxidative stress, inflammation, fibrosis, coagulation and renal impairment. Each of these has different utility in current clinincal practice.
机标关键词：managementclinicalheartwithatrialbiomarkersfailurefibrillation
论文发表日期：2021-11-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：44( 908-951 )