Association between serum cystatin C level and hemodynamically significant aortic stenosis: a prospective cohort study
Odong Christopher1
Xing-Feng XU1
Yi-Fen LIN1
Shao-Zhao ZHANG1
Yi-Quan HUANG1
Xiang-Bin ZHONG1
Zhen-Yu XIONG1
Tara Scarlett Rosalyn CHEN2
Chao-Guang XU1
Xiao-Dong ZHUANG1
Xin-Xue LIAO1
1.Department of Cardiology,the First Affiliated Hospital of Sun Yat-Sen University,Guangzhou,China;NHC Key Lab-oratory of Assisted Circulation,Sun Yat-Sen University,Guangzhou,China2.Department of Rehabilitation Medicine,the Seventh Affiliated Hospital of Sun Yat-Sen University,Shenzhen,China
摘要：BACKGROUND Cystatin C (CysC) is a cysteine protease inhibitor involved in proteins catabolism and plays an essential role in human vascular pathophysiology. CysC may also increase the risk of aortic stenosis (AS), but limited studies have reported on this association. This study aimed to investigate if elevated serum CysC levels are associated with hemodynamically significant AS. METHODS Serum CysC levels were estimated in 4,791 participants, samples were collected in 1990?1992. The study popula-tion was divided into quintile groups. Follow-up continued in 2011–2013 when participants returned for echocardiography exam-ination. Incidence of aortic valve disease (AVD) was ascertained by Doppler echocardiography through the end of 2013. AVD defined in hemodynamic progression was assessed and classified as aortic sclerosis, mild stenosis, and moderate-to-severe sten-osis. RESULTS Overall, a total of 4,791 participants (mean age: 54.8 ± 5.0 years, females: 57.6％, blacks: 8.2％) were included in this study. During a follow-up of 21 years, we identified 736 cases (15.4％) of aortic sclerosis, 194 cases (4.0％) of mild stenosis, and 42 cases (0.7％) of moderate-to-severe stenosis. Compared with serum CysC levels within individual quintile groups, the odds ratio (OR) was per standard deviation associated with an increased incidence of AVD (OR = 1.15, 95％ CI: 1.05?1.26, P = 0.002). CONCLUSIONS In this large population-based study, an increased serum CysC levels is independently associated with the incidence of hemodynamically significant AS. However, this association appears not to extend to patients with extremely high serum CysC levels and necessitate further investigation.
机标关键词：associationcystatinbetweenstudylevelaorticcohorthemodynamically
论文发表日期：2021-12-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 986-995 )