The influence of metabolic syndrome on atrial fibrillation recurrence: five-year outcomes after a single cryoballoon ablation procedure
Yu XIA
Xiao-Feng LI
Jun LIU
Miao YU
Pi-Hua FANG
Shu ZHANG
State Key Laboratory of Cardiovascular Disease,Cardiac Arrhythmia Center,Fuwai Hospital,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China
摘要：BACKGROUND Metabolic syndrome (MetS) has been reported as a risk factor of atrial fibrillation (AF) recurrence after radi-ofrequency catheter ablation. This study aimed to investigate the long-term influence of MetS on paroxysmal AF recurrence after a single cryoballoon ablation procedure, which was scarcely investigated yet in Chinese population. METHODS In total, 137 paroxysmal AF patients who had successfully completed a single cryoballoon ablation procedure at Fuwai Hospital, Beijing, China from December 2013 to October 2015 were enrolled. Excepting for patients with AF recurrence, all patients were followed up for no less than five years. Independent predictors of AF recurrence were determined by Cox propor-tional hazards regression analysis. RESULTS Among 137 paroxysmal AF patients, 91 patients (66.4％) had successfully achieved overall five-year follow-up after a single cryoballoon ablation procedure, and 44 patients (32.1％) had MetS. Patients with MetS had a significant lower incidence of freedom from AF recurrence than those without MetS (50.0％ vs. 74.2％, log-rank P < 0.01) during the five-year follow-up. MetS (HR = 1.95, 95％ CI: 1.069?3.551, P = 0.030) was an independent predictor of AF recurrence after adjusting for multiple factors. After the second year post cryoballoon ablation procedure, the recurrence rate of AF gradually increased in patients with MetS, in con-trast, decreased recurrence rate of AF in patients without MetS. CONCLUSIONS MetS is an independent predictor for five-year AF recurrence after a single cryoballoon ablation procedure in paroxysmal AF patients. Combination therapy of AF and MetS may improve the long-term outcomes of AF patients.
机标关键词：metabolicsingleafterablationatrialcryoballoonfibrillationfive-year
论文发表日期：2021-12-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 1019-1028 )