Energy metabolism homeostasis in cardiovascular diseases
Lu-Yun WANG
Chen CHEN
Division of Cardiology,Tongji Hospital,Tongji Medical College and Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiologic Disorders,Huazhong University of Science and Technology,Wuhan,China
摘要：Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the general population. Energy metabolism disturbance is one of the early abnormalities in CVDs, such as coronary heart disease, diabetic cardiomyopathy, and heart failure. To explore the role of myocardial energy homeostasis disturbance in CVDs, it is important to understand myocardial metabolism in the normal heart and their function in the complex pathophysiology of CVDs. In this article, we summarized lipid metabolism/lipotoxicity and glucose metabolism/insulin resistance in the heart, focused on the metabolic regulation during neo-natal and ageing heart, proposed potential metabolic mechanisms for cardiac regeneration and degeneration. We provided an over-view of emerging molecular network among cardiac proliferation, regeneration, and metabolic disturbance. These novel targets promise a new era for the treatment of CVDs.
机标关键词：energycardiovasculardiseaseshomeostasismetabolism
论文发表日期：2021-12-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：14( 1044-1057 )