Alcohol consumption in relation to the incidence of atrial fibrillation in an elderly Chinese population
Xiao-Fei YE1
Wei ZHANG2
Yi CHEN2
Chao-Ying MIAO1
Qi-Fang HUANG2
Chang-Sheng SHENG2
Shuai SHAO2
Dian WANG2
Shao-Kun XU2
Lei LEI2
Di ZHANG2
Yi-Lin CHEN2
Lei-Xiao HU2
Jia-Hui XIA2
Yi-Bang CHENG2
Ying WANG2
Qian-Hui GUO2
Yan LI2
Nicole Lowres3
Ben Freedman3
Ji-Guang WANG4
1.School of Public Health,Shanghai Jiao Tong University School of Medicine,Shanghai,China2.Department of Cardiovascular Medicine,The Shanghai Institute of Hypertension,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,China3.Heart Research Institute,Sydney Medical School,Charles Perkins Center,and Cardiology Department,Concord Hospital,University of Sydney,Sydney,Australia4.School of Public Health,Shanghai Jiao Tong University School of Medicine,Shanghai,China;Department of Cardiovascular Medicine,The Shanghai Institute of Hypertension,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,China
摘要：BACKGROUND Alcohol consumption is a known modifiable risk factor for atrial fibrillation. The association, however, might differ according to gender. We investigated gender-specific associations between alcohol consumption and incident atrial fibrilla-tion in an elderly Chinese population.METHODS Our study participants were elderly residents (≥ 65 years) recruited from five community health centers in the urban area of Shanghai (n = 6,618). Alcohol intake was classified as never drinkers and current light-to-moderate (< 40 g/day) and heavy drinkers (≥ 40 g/day). Atrial fibrillation was detected by a 30-s single-lead electrocardiography (ECG, AliveCor? Heart Monitor) and further evaluated with a regular 12-lead ECG. RESULTS During a median of 2.1 years (interquartile range: 2.0?2.2) follow-up, the incidence rate of atrial fibrillation was 1.10％ in all study participants. It was slightly but non-significantly higher in men (n = 2849) than women (n = 3769, 1.30％ vs. 0.96％, P = 0.19) and in current drinkers (n = 793) than never drinkers (n = 5825, 1.64％ vs. 1.03％, P = 0.12). In both unadjusted and adjusted analyses, there was interaction between sex and current alcohol intake in relation to the incidence of atrial fibrillation (P < 0.0001). After adjustment for confounding factors, current drinkers had a significantly higher incidence rate of atrial fibrilla-tion than never drinkers in women (12.96％ [7/54] vs. 0.78％ [29/3715], adjusted odds ratio [OR] = 10.25, 95％ confidence interval [CI]: 3.54?29.67, P < 0.0001), but not in men (0.81％ [6/739] vs. 1.47％ [31/2110], OR = 0.62, 95％ CI: 0.25?1.51, P = 0.29). CONCLUSIONS Our study showed a significant association between alcohol intake and the incidence of atrial fibrillation in elderly Chinese women, but not men.
机标关键词：populationchineserelationalcoholatrialconsumptionelderlyfibrillation
论文发表日期：2022-01-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 52-60 )