Assessment of causal direction between thyroid function and cardiometabolic health: a Mendelian randomization study
Jing-Jia WANG1
Zhen-Huang ZHUANG2
Can-Qing YU2
Wen-Yao WANG1
Wen-Xiu WANG2
Kuo ZHANG1
Xiang-Bin MENG3
Jun GAO3
Jian TIAN1
Ji-Lin ZHENG1
Jie YANG1
Tao HUANG4
Chun-Li SHAO3
Yi-Da TANG3
1.Department of Cardiology,State Key Laboratory of Cardiovascular Disease,Fuwai Hospital,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China2.Department of Epidemiology&Biostatistics,School of Public Health,Peking University,Beijing,China;Center for Intelligent Public Health,Academy for Artificial Intelligence,Peking University,Beijing,China3.Department of Cardiology and Institute of Vascular Medicine,Peking University Third Hospital,Beijing,China4.Department of Epidemiology&Biostatistics,School of Public Health,Peking University,Beijing,China;Center for Intelligent Public Health,Academy for Artificial Intelligence,Peking University,Beijing,China;Key Laboratory of Molecular Cardiovascular Sciences(Peking University),Ministry of Education,Beijing,China
摘要：BACKGROUND Growing evidence have demonstrated that thyroid hormones have been involved in the processes of cardi-ovascular metabolism. However, the causal relationship of thyroid function and cardiometabolic health remains partly unknown. METHODS The Mendelian randomization (MR) was used to test genetic, potentially causal relationships between instrument-al variables and cardiometabolic traits. Genetic variants of free thyroxine (FT4) and thyrotropin (TSH) levels within the reference range were used as instrumental variables. Data for genetic associations with cardiometabolic diseases were acquired from the genome-wide association studies of the FinnGen, CARDIoGRAM and CARDIoGRAMplusC4D, CHARGE, and MEGASTROKE. This study was conducted using summary statistic data from large, previously described cohorts. Association between thyroid function and essential hypertension (EHTN), secondary hypertension (SHTN), hyperlipidemia (HPL), type 2 diabetes mellitus (T2DM), ischemic heart disease (IHD), myocardial infarction (MI), heart failure (HF), pulmonary heart disease (PHD), stroke, and non-rheumatic valve disease (NRVD) were examined. RESULTS Genetically predicted FT4 levels were associated with SHTN (odds ratio = 0.48; 95％ CI = 0.04?0.82, P = 0.027), HPL (odds ratio = 0.67; 95％ CI = 0.18?0.88, P = 0.023), T2DM (odds ratio = 0.80; 95％ CI = 0.42?0.86, P = 0.005), IHD (odds ratio = 0.85;95％ CI = 0.49?0.98, P = 0.039), NRVD (odds ratio = 0.75; 95％ CI = 0.27?0.97, P = 0.039). Additionally, genetically predicted TSH levels were associated with HF (odds ratio = 0.82; 95％ CI = 0.68?0.99, P = 0.042), PHD (odds ratio = 0.75; 95％ CI = 0.32?0.82, P =0.006), stroke (odds ratio = 0.95; 95％ CI = 0.81?0.97, P = 0.007). However, genetically predicted thyroid function traits were not as-sociated with EHTN and MI. CONCLUSIONS Our study suggests FT4 and TSH are associated with cardiometabolic diseases, underscoring the importance of the pituitary-thyroid-cardiac axis in cardiometabolic health susceptibility.
机标关键词：betweenfunctionstudyassessmentcardiometaboliccausaldirectionhealth
论文发表日期：2022-01-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 61-70 )