Relationship of body fat and left ventricular hypertrophy with the risk of all-cause death in patients with coronary artery disease
Bao-Tao HUANG1
Lu YANG2
Bo-Sen YANG1
Fang-Yang HUANG1
Qian-Feng XIAO1
Xiao-Bo PU1
Yong PENG1
Mao CHEN1
1.Department of Cardiology,West China Hospital,Sichuan University,Chengdu,Sichuan,China2.Department of Cardiology,West China Hospital,Sichuan University/West China School of Nursing,Sichuan University,Chengdu,Sichuan,China
摘要：BACKGROUND Left ventricular hypertrophy (LVH) is prevalent in obese individuals. Besides, both of LVH and obesity is as-sociated with subclinical LV dysfunction. The study aims to investigate the interplay between body fat and LVH in relation to all-cause death in patients with coronary artery disease (CAD). METHODS In this retrospective cohort study, a total of 2243 patients with angiographically proven CAD were included. Body fat and LV mass were calculated using established formulas. Patients were grouped according to body fat percentage and pres-ence or absence of LVH. Cox-proportional hazard models were used to observe the interaction effect of body fat and LVH on all-cause death. RESULTS Of 2243 patients enrolled, 560 (25％) had a higher body fat percentage, and 1045 (46.6％) had LVH. After a median follow-up of 2.2 years, the cumulative mortality rate was 8.2％ in the group with higher body fat and LVH, 2.5％ in those with lower body fat and no LVH, 5.4％ in those with higher body fat and no LVH, and 7.8％ in those with lower body fat and LVH (log-rank P < 0.001). There was a statistically significant interaction between body fat percentage and LVH (P interaction was 0.003). After correcting for confounding factors, patients with higher body fat and LVH had the highest risk of all-cause death (HR =3.49, 95％ CI: 1.40–8.69, P = 0.007) compared with those with lower body fat and no LVH; in contrast, patients with higher body fat and no LVH had no statistically significant difference in risk of death compared with those with lower body fat and no LVH (HR =2.03, 95％ CI: 0.70–5.92, P = 0.195). CONCLUSION A higher body fat percentage was associated with a different risk of all-cause death in patients with CAD, strat-ified by coexistence of LVH or not. Higher body fat was significantly associated with a greater risk of mortality among patients with LVH but not among those without LVH.
机标关键词：relationshipriskwithall-causearterybodycoronarydeath
论文发表日期：2022-03-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 218-226 )