Ambulatory diastolic blood pressure: a marker of comorbidity in elderly fit hypertensive individuals?
Alfredo De Giorgi1
Rosaria Cappadona2
Caterina Savriè1
Benedetta Boari1
Ruana Tiseo1
Giulia Marta Viglione1
Christian Molino1
Elisa Misurati1
Mauro Pasin3
Roberto Manfredini3
Fabio Fabbian3
1.Clinica Medica Unit,Azienda Ospedaliero-Universitaria S.Anna,Ferrara,Italy2.Department of Medical Sciences,University of Ferrara,Ferrara,Italy3.Clinica Medica Unit,Azienda Ospedaliero-Universitaria S.Anna,Ferrara,Italy;Department of Medical Sciences,University of Ferrara,Ferrara,Italy
摘要：BACKGROUND Masked diastolic hypotension is a new blood pressure (BP) pattern detected by ambulatory blood pressure monitoring (ABPM) in elderly hypertensives. The aim of this study was to relate ABPM and comorbidity in a cohort of fit elderly subjects attending an outpatient hypertension clinic. METHODS Comorbidity was assessed by Charlson comorbidity index (CCI) and CHA2DS2VASc score. All subjects evaluated with ABPM were aged ≥ 65 years. CCI and CHA2DS2VASc score were calculated. Diastolic hypotension was defined as mean am-bulatory diastolic BP < 65 mmHg and logistic regression analysis was carried out in order to detect and independent relationship between comorbidity burden and night-time diastolic BP < 65 mmHg. RESULTS We studied 174 hypertensive elderly patients aged 72.1 ± 5.2 years, men were 93 (53.4％). Mean CCI was 0.91 ± 1.14 and mean CHA2DS2VASc score of 2.68 ± 1.22. Subjects with night-time mean diastolic values < 65 mmHg were higher in females [54.7％ vs. 45.3％, P = 0.048; odds ratio (OR) = 1.914, 95％ CI: 1.047?3.500]. Logistic regression analysis showed that only CHA2DS2-VASc score was independently associated with night-time mean diastolic values < 65 mmHg (OR = 1.518, 95％ CI: 1.161?1.985; P =0.002), but CCI was not. CONCLUSIONS ABPM and comorbidity evaluation appear associated in elderly fit subjects with masked hypotension. Com-orbid women appear to have higher risk for low ambulatory BP.
机标关键词：pressuremarkerbloodambulatorycomorbiditydiastolicelderlyhypertensive
论文发表日期：2022-04-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：11( 254-264 )