Effects of chronic obstructive pulmonary disease on long-term prognosis of patients with coronary heart disease post-percutaneous coronary intervention
Yi YAO
Pei ZHU
Na XU
Lin JIANG
Xiao-Fang TANG
Ying SONG
Xue-Yan ZHAO
Shu-Bin QIAO
Yue-Jin YANG
Jin-Qing YUAN
Run-Lin GAO
Center for Coronary Heart Disease,National Center for Cardiovascular Diseases,State Key Laboratory of Cardiovascular Disease,Fuwai Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China
摘要：BACKGROUND Chronic obstructive pulmonary disease (COPD) and cardiovascular diseases are often comorbid conditions, their co-occurrence yields worse outcomes than either condition alone. This study aimed to investigate COPD impacts on the five-year prognosis of patients with coronary heart disease (CHD) after percutaneous coronary intervention (PCI). METHODS Patients with CHD who underwent PCI in 2013 were recruited, and divided into COPD group and non-COPD gr-oup. Adverse events occurring among those groups were recorded during the five-year follow-up period after PCI, including all-cause death and cardiogenic death, myocardial infarction, repeated revascularization, as well as stroke and bleeding events. Ma-jor adverse cardiac and cerebral events were a composite of all-cause death, myocardial infarction, repeated revascularization and stroke. RESULTS A total of 9843 patients were consecutively enrolled, of which 229 patients (2.3％) had COPD. Compared to non-COPD patients, COPD patients were older, along with poorer estimated glomerular filtration rate and lower left ventricular ejection frac-tion. Five-year follow-up results showed that incidences of all-cause death and cardiogenic death, as well as major adverse cardiac and cerebral events, for the COPD group were significantly higher than for non-COPD group (10.5％ vs. 3.9％, 7.4％ vs. 2.3％, and 30.1％vs. 22.6％, respectively). COPD was found under multivariate Cox regression analysis, adjusted for confounding factors, to be an independent predictor of all-cause death [odds ratio (OR) = 1.76, 95％ CI: 1.15–2.70, P = 0.009] and cardiogenic death (OR = 2.02, 95％ CI: 1.21–3.39, P = 0.007). CONCLUSIONS COPD is an independent predictive factor for clinical mortality, in which CHD patients with COPD are asso-ciated with worse prognosis than CHD patients with non-COPD.
机标关键词：percutaneousprognosisheartpostwithchroniccoronarydisease
论文发表日期：2022-06-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 428-434 )