Prognostic significance of multiple triglycerides-derived met-abolic indices in patients with acute coronary syndrome
Qiao-Yu SHAO
Xiao-Teng MA
Zhi-Qiang YANG
Qiu-Xuan LI
Yu-Fei WANG
Jing LIANG
Hua SHEN
Xiao-Li LIU
Yu-Jie ZHOU
Dong-Mei SHI
Zhi-Jian WANG
Department of Cardiology,Beijing Anzhen Hospital,Capital Medical University,Beijing,China*The authors contributed equally to this manuscript
摘要：BACKGROUND Triglyceride (TG) and its related metabolic indices, all recognized as surrogates of insulin resistance, have been demonstrated to be relevant to clinical prognosis. However, the relative value of these TG-related indices for predicting car-diovascular events among patients with acute coronary syndrome (ACS) has not been examined. METHODS The TG, the triglyceride-glucose (TyG) index, the atherogenic index of plasma, TG to high-density lipoprotein cho-lesterol ratio, and the lipoprotein combine index were assessed in 1694 ACS patients undergoing percutaneous coronary interv-ention. The primary endpoint was major adverse cardiovascular event (MACE), which was the composite of all-cause mortality, stroke, myocardial infarction, or unplanned repeat revascularization. RESULTS During a median follow-up of 31 months, 345 patients (20.4％) had MACE. The risk of the MACE was increased with higher TG and the four TG-derived metabolic indices [TG-adjusted hazard ratio (HR) = 1.002, 95％ CI: 1.001–1.003; TyG index-ad-justed HR = 1.736, 95％ CI: 1.398–2.156; atherogenic index of plasma-adjusted HR = 2.513, 95％ CI: 1.562–4.043; TG to high-density lipoprotein cholesterol ratio-adjusted HR = 1.148, 95％ CI: 1.048–1.258; and lipoprotein combine index-adjusted HR = 1.009, 95％CI: 1.004–1.014; P < 0.001 for all indices]. TG and all the four indices significantly improved the predictive ability for MACE in ad-dition to the baseline model. Among them, TyG index showed the best ability for predicting MACE compared with the other three indices from all the three measurements (P < 0.05 for all comparison). CONCLUSIONS TG and TG-derived metabolic indices were all strongly associated with MACE among ACS patients under-going percutaneous coronary intervention. Among all the indices, TyG index showed the best ability to predict the risk of MACE.
机标关键词：significancewithacutecoronaryderivedindicesmet-abolicmultiple
论文发表日期：2022-06-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：13( 456-468 )