Association of baseline hemoglobin A1c levels with bleeding in patients with non-ST-segment elevation acute coronary syndrome underwent percutaneous coronary intervention:insights of a multicenter cohort study from China
Hua-Lin FAN1
Li-Huan ZENG2
Peng-Yuan CHEN3
Yuan-Hui LIU4
Chong-Yang DUAN5
Wen-Fei HE3
Ning TAN4
Ji-Yan CHEN4
Peng-Cheng HE6
1.Department of Cardiology,School of Medicine,South China University of Technology,Guangzhou,China;Department of Cardiology,Guangdong Cardiovascular Institute,Guangdong Provincial People's Hospital,Guangdong Academy of Medical Sciences,Guangzhou,China;Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention,Guangdong Provincial People's Hospital,Guangdong Academy of Medical Sciences,Guangzhou,China2.The Second School of Clinical Medicine,Southern Medical University,Guangzhou,China3.Department of Cardiology,the Second People's Hospital of Nanhai District,Guangdong Provincial People's Hospital's Nanhai Hospital,Foshan,China4.Department of Cardiology,Guangdong Cardiovascular Institute,Guangdong Provincial People's Hospital,Guangdong Academy of Medical Sciences,Guangzhou,China;Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention,Guangdong Provincial People's Hospital,Guangdong Academy of Medical Sciences,Guangzhou,China5.De-partment of Biostatistics,School of Public Health,Southern Medical University,Guangzhou,China6.Department of Cardiology,School of Medicine,South China University of Technology,Guangzhou,China;Department of Cardiology,Guangdong Cardiovascular Institute,Guangdong Provincial People's Hospital,Guangdong Academy of Medical Sciences,Guangzhou,China;Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention,Guangdong Provincial People's Hospital,Guangdong Academy of Medical Sciences,Guangzhou,China;The Second School of Clinical Medicine,Southern Medical University,Guangzhou,China;Department of Cardiology,Heyuan People's Hospital,Heyuan,China
摘要：OBJECTIVE To investigate the association between baseline hemoglobin A1c (HbA1c) levels and bleeding in patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS) who underwent percutaneous coronary intervention (PCI). METHODS This observational cohort study enrolled 6283 consecutive NSTE-ACS patients undergoing PCI from January 1, 2010 to December 31, 2014. Based on baseline HbA1c levels, the patients were divided into the group with HbA1c < 7％ (n =4740) and the group with HbA1c ≥ 7％ (n = 1543). The primary outcomes are major bleeding (BARC grades 3-5) and all-cause death during follow-up. RESULTS Of patients enrolled, 4705 (74.9％) were male, and 2143 (34.1％) had a history of diabetes mellitus, with a mean (SD) age of 64.13 (10.32) years. The median follow-up duration was 3.21 years. Compared with the patients with HbA1c < 7％, the risk of major bleeding events during follow-up was higher in patients with HbA1c ≥ 7％ (adjusted hazard ratio [HR] = 1.57; 95％ con-fidence interval [CI]: 1.01-2.44; P = 0.044), while the risk of all-cause death during follow-up was not associated with the higher HbA1c levels (adjusted HR = 0.88; 95％ CI: 0.66-1.18; P = 0.398). CONCLUSIONS Compared with the lower baseline HbA1c levels, the higher baseline HbA1c levels were associated with an increase in long-term bleeding risk in NSTE-ACS patients undergoing PCI, though higher baseline HbA1c levels were not associ-ated with the higher risk in all-cause death.
机标关键词：associationpercutaneousinsightsbaselinelevelsstudywithchina
论文发表日期：2022-07-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：11( 487-497 )