Inflammation-based different association between anatomical severity of coronary artery disease and lung cancer
Ya-Wei ZHAO1
Kai-Xin YAN1
Ming-Zhuang SUN1
Yi-Hao WANG1
Yun-Dai CHEN2
Shun-Ying HU2
1.Department of Cardiology,Chinese PLA General Hospital,Beijing,China;Medical School of Chinese PLA,Beijing,China2.Department of Cardiology,Chinese PLA General Hospital,Beijing,China
摘要：BACKGROUND Coronary artery disease (CAD) is associated with cancer. The role of inflammation in the association of CAD with cancer remains unclear. The study investigated whether inflammation could impact the relationship between CAD and lung cancer.METHODS The study involved 96 newly diagnosed lung cancer patients without receiving anti-cancer therapy and 288 matched non-cancer patients. All the patients underwent coronary angiography and were free from previous percutaneous coronary inter-vention or coronary artery bypass grafting. SYNTAX score (SXscore) were used to assess severity of CAD. High SXscore (SXhigh) grade was defined as SXscore > 16 (highest quartile). Neutrophil-to-lymphocyte ratio (NLR) served as an inflammatory biomarker. NLR-high grade referred to NLR > 2.221 (median). RESULTS Among 384 study patients, 380 patients (98.96％) had NLR value (median: 2.221, interquartile range: 1.637–3.040). Com-pared to non-cancer patients, lung cancer patients had higher rate of SXhigh among total study patients (P = 0.014) and among pat-ients with NLR-high (P = 0.006), but had not significantly higher rate of SXhigh among patients with NLR-low (P = 0.839). Multiv-ariate logistic regression analysis showed that SXhigh was associated with lung cancer [odds ratio (OR) = 1.834, 95％ CI: 1.063–3.162, P = 0.029]. Subgroup analysis showed that SXhigh was associated with lung cancer among patients with NLR-high (OR =2.801, 95％ CI: 1.355–5.794, P = 0.005), however, the association between SXhigh and lung cancer was not significant among pati-ents with NLR-low (OR = 0.897, 95％ CI: 0.346–2.232, P = 0.823). CONCLUSIONS Inflammation could lead different association between anatomical severity of CAD and lung cancer. Severity of CAD was significantly associated with increased risk of lung cancer among patients with high inflammation rather than am-ong patients with low inflammation.
机标关键词：associationdifferentbetweencanceranatomicalarterybasedcoronary
论文发表日期：2022-08-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 575-582 )