Serum triglycerides concentration in relation to total and cardiovascular mortality in an elderly Chinese population
Chao-Ying MIAO1
Xiao-Fei YE1
Wei ZHANG2
Chang-Sheng SHENG2
Qi-Fang HUANG2
Ji-Guang WANG3
1.School of Public Health,Shanghai Jiao Tong University School of Medicine,Shanghai,China2.Department of Cardi-ovascular Medicine,the Shanghai Institute of Hypertension,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,China3.School of Public Health,Shanghai Jiao Tong University School of Medicine,Shanghai,China;Department of Cardi-ovascular Medicine,the Shanghai Institute of Hypertension,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,China
摘要：OBJECTIVE To investigate serum triglycerides in relation to all-cause, cardiovascular, and non-cardiovascular mortality in an elderly Chinese population.METHODS The study participants (n = 3565) were elderly (≥ 60 years) community dwellers living in a suburban town of Shanghai. Hypertriglyceridemia was defined as a serum triglycerides concentration ≥ 2.30 mmol/L (definite) and ≥ 1.70 mmol/L (borderline), respectively. RESULTS The prevalence of definite and borderline hypertriglyceridemia at baseline was 7.5％ and 29.5％, respectively. It was higher in women (n = 1982, 9.0％ and 33.8％, respectively) than men (n = 1583, 6.2％ and 27.9％, respectively), in obese and over-weight participants (n = 1566, 10.5％ and 36.4％, respectively) than normal weight participants (n = 1999, 5.6％ and 27.1％, respect-ively), and in diabetic participants (n = 177, 11.9％ and 39.0％, respectively) than non-diabetic participants (n = 3388, 7.5％ and 30.8％, respectively). During a median of 7.9 years follow-up, all-cause, cardiovascular and non-cardiovascular deaths occurred in 529, 216 and 313 participants, respectively. In analyses according to the quintile distributions of serum triglycerides concentration, the sex- and age-standardized mortality rate was lowest in the middle quintile for all-cause, cardiovascular and non-cardiovascu-lar mortality (18.6, 7.8 and 11.9 per 1000 person-years, respectively, versus 21.5, 10.5 and 12.7 per 1000 person-years, respectively, in the two lower quintiles and 21.7, 9.5 and 14.0 per 1000 person-years, respectively, in the two higher quintiles). The fully adjus-ted hazard ratios (95％ CI) for the middle quintile versus the combined two lower with two higher quintiles were 0.85 (95％ CI:0.67–1.07, P = 0.17), 0.81 (95％ CI: 0.54–1.19, P = 0.28) and 0.87 (95％ CI: 0.64–1.17, P = 0.35) for all-cause, cardiovascular and non-cardiovascular mortality, respectively. CONCLUSIONS Our study showed high prevalence of hypertriglyceridemia, especially when defined as borderline and in obese and overweight participants, and mildly but non-significantly elevated risks of cardiovascular mortality relative to the middle level of serum triglycerides.
机标关键词：populationrelationchinesetotalcardiovascularconcentrationelderlymortality
论文发表日期：2022-08-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 603-609 )