Positive association between triglyceride glucose index and central systolic blood pressure among hypertensive adults
Li WANG1
Tian-Yu CAO2
Jin-Qiao LI3
Cong-Cong DING4
Jun-Pei LI4
Hua-Bo YING4
Li-Shun LIU5
Xiao HUANG4
1.Department of Nephrology,the Fourth Hospital of Harbin Medical University,Harbin,China2.Biological Anthropo-logy,University of California Santa Barbara,California,USA3.Department of Urology Surgery,Graduate School of the Fourth Hospital of Harbin Medical University,Harbin,China4.Department of Cardiology,the Second Affiliated Hospi-tal of Nanchang University,Nanchang,China5.Institute of Biomedicine,Anhui Medical University,Hefei,China;Instit-ute of Biomedical and Health Engineering,Graduate School at Shenzhen,Tsinghua University,Shenzhen,China;Shen-zhen Evergreen Medical Institute,Shenzhen,China
摘要：BACKGROUND While studies have suggested the association between triglyceride-glucose (TyG) index, a reliable surrogate for insulin resistance and hypertension data are limited to the correlation of TyG and central blood pressure. This study aims to test the hypothesis that a higher TyG index is associated with elevated central systolic blood pressure (cSBP).METHODS A total of 9249 Chinese hypertensive adults from the H-type Hypertension and Stroke Prevention and Control Project were analyzed in this study. cSBP was measured noninvasively using an A-Pulse CASPro device. TyG index was calculated as ln [fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]. Smoothing curve and multivariate linear regression models [beta coefficient (β) with 95％ CI] were applied to analyze the association between TyG index and cSBP. Subgroup analyses were conducted to explore potential modifications to such a correlation. RESULTS The overall mean TyG index is 8.8 ± 0.7, and the total mean cSBP is 131.3 ± 12.8 mmHg. TyG index was observed to be independently and positively associated with cSBP among the total population (β= 0.92, 95％ CI: 0.53–1.31, P < 0.001), and par-ticipants who do not use antihypertensive drugs (β= 1.03, 95％ CI: 0.46–1.60, P < 0.001), which is in accordance with the result of the smoothing curve. The association between TyG index and cSBP appears robust in all tested subgroups. CONCLUSIONS TyG index is positively and independently associated with cSBP among hypertensive adults. Our study res-ult suggests that TyG index might serve as an effective marker for vascular function.
机标关键词：associationpressurecentralsystolicglucosebetweenbloodindex
论文发表日期：2022-10-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 753-760 )