Acute perimyocarditis following heterologous vaccination of CoronaVac and BNT162b2 SARS-CoV-2 vaccine in an elderly woman
Shing Ching
Chiu Sun Yue
Division of Cardiology,Department of Medicine and Geriatrics,United Christian Hospital,Hong Kong,China
摘要：Inactivated and mRNA SARS-CoV-2 vaccinesare highly efficacious in preventing severe di-sease and mortality. As the antibody level wa-nes over time,[1] booster vaccination is recommen-ded by the World Health Organization after compl-etion of basic vaccination sequence.[2] Heterologous compared to homologous boosting is found to be more immunogenic, generate higher antibody le-vels and may reduce the risk of breakthrough infec-tions.[3] For example, health authorities in Hong Kong and Singapore recommend mRNA vaccines as bo-oster for inactivated vaccine-primed individuals. mRNA vaccines including BNT162b2 and mRNA-1273 are associated with higher risk of myocarditis predominantly in young males,[4] which is also ob-served in mRNA vaccine-boosted, AZD1222-pri-med individuals.[5] However, myocarditis risk is un-known in individuals who are primed with inactiv-ated and heterologously boosted with mRNA vac-cines, particularly in the elderly population.
机标关键词：sars-cov-2acutecoronavacelderlyfollowingheterologousperimyocarditisvaccination
论文发表日期：2022-10-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：3( 785-787 )