Development and validation of a nomogram predicting one-year mortality in patients undergoing percutaneous coronary intervention
Jing-Jing SONG1
Yu-Peng LIU2
Wen-Yao WANG3
Jie YANG1
Jun WEN1
Jing CHEN1
Jun GAO3
Chun-Li SHAO3
Yi-Da TANG3
1.Department of Cardiology,State Key Laboratory of Cardiovascular Disease,Fuwai Hospital,National Center for Car-diovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China2.Depa-rtment of Cardiology,Guangdong Cardiovascular Institute,Guangdong Provincial People's Hospital,Guangdong Acad-emy of Medical Sciences,Guangzhou,China3.Department of Cardiology and Institute of Vascular Medicine,Peking University Third Hospital,Key Laboratory of Molecular Cardiovascular Science,Ministry of Education,Beijing,China
摘要：OBJECTIVE To formulate a nomogram to predict the risk of one-year mortality after percutaneous coronary intervention (PCI) based on a large-scale real-world Asian cohort.METHODS This study cohort included consecutive patients undergoing PCI in the National Center for Cardiovascular Dise-ases of China. The endpoint was all-cause mortality. Least absolute shrinkage and selection operator Cox regression and backw-ard stepwise regression were used to select potential risk factors. A nomogram based on the predictors was accordingly const-ructed to predict one-year mortality. The performance of the nomogram was evaluated. Patients were stratified into low-, inter-mediate- and high-risk groups according to the tertile points in the nomogram and compared by the Kaplan-Meier analysis. RESULTS A total of 9603 individuals were included in this study and randomly divided into the derivation cohort (60％) and the validation cohort (40％). Six variables were selected to formulate the nomogram, including age, renal insufficiency, cardiac dysfunction, previous cerebrovascular disease, previous PCI, and TIMI 0–1 before PCI. The area under the curve of this nomo-gram regarding one-year mortality risks were 0.792 and 0.754 in the derivation cohort and validation cohort, respectively. Kap-lan-Meier curve successfully stratified the patients according to three risk groups. This nomogram calibrated well and exhibited satisfactory clinical utility in the decision curve analysis. CONCLUSIONS This study developed and validated a simple-to-use nomogram predicting one-year mortality risk in Asian patients undergoing PCI and could help clinicians make risk-dependent decisions.
机标关键词：developmentpercutaneousnomogramcoronaryinterventionmortalityone-yearpatients
论文发表日期：2022-12-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 960-969 )