Ascending aorta dilatation reduces the influence of elevated pulse pressure on left ventricular hypertrophy: findings from a Chinese elderly hypertensive population
Yu-Qi JIANG
Huan-Rui ZHANG
Bo-Nan LIU
Tian-Wen LI
Jun-Feng JIANG
Wen TIAN
Department of Geriatrics,the First Hospital of China Medical University,Shenyang,China
摘要：OBJECTIVE To determine the role of ascending aorta dilatation in the relationship between pulse pressure (PP) and left vent-ricular (LV) hypertrophy. METHODS A total of 1556 Chinese elderly hypertensive patients were retrospectively studied. Transthoracic echocardiography was used to obtain the aortic and cardiac structure measurements. In addition, brachial blood pressure was measured, and total arterial compliance, systemic vascular resistance, arterial elastance, and end-systolic LV elastance were calculated. The participants were divided into four groups according to the status of ascending aortic diameter and PP. RESULTS LV mass index increased in succession in the four groups, i.e., the group with the normal aorta and lower PP, with the normal aorta and higher PP, with aortic dilatation and lower PP, and with aortic dilatation and higher PP (Ptrend < 0.001). Total arterial compliance?1, arterial elastance, and end-systolic LV elastance were slightly higher in the individuals with normal aorta com-pared to those with aortic dilatation, regardless of PP being lower or higher (P < 0.01). Compared to the group with the normal aorta and lower PP, individuals with aortic dilatation had a significantly increased multivariable adjusted risk of LV hypertrophy, and higher PP further exacerbated this risk [aortic dilatation with lower PP (OR = 1.75, 95％ CI: 1.01–3.04) and aortic dilatation with hig-her PP (OR = 3.42, 95％ CI: 2.03–5.77)]. In the relation between PP and LV mass index (β = 0.095, P < 0.001), -41.3％ of the total effect was attributable to mediation by ascending aortic diameter (P < 0.0001). CONCLUSIONS In Chinese elderly patients with hypertension, ascending aorta dilatation could reduce the influence of elev-ated PP on LV hypertrophy.
机标关键词：populationpressurechinesepulsefromaortaascendingdilatation
论文发表日期：2023-02-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 100-108 )