Effect of renal denervation for patients with isolated systolic hypertension: a systematic review and meta-analysis
Le LI
Yu-Long XIONG
Bin TU
Shang-Yu LIU
Zhen-Hao ZHANG
Zhao HU
Yan YAO
Department of Cardiology,Fuwai Hospital,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China
摘要：BACKGROUND Renal denervation (RDN) is a promising treatment based on catheter intervention for patients with refract-ory hypertension. However, the effect in patients with isolated systolic hypertension (ISH) remains controversial. The aim of this meta-analysis was to determine the blood pressure lowing effect of RDN in patients with ISH compared with combined systolic/diastolic hypertension (CH) patients. METHODS PubMed, Embase, Cochrane and ClinicalTrials.gov were searched for prospective clinical studies that included RDN. The outcomes of interest were the change of 24-hour ambulatory systolic blood pressure (SBP) from baseline. We used the fixed eff-ects model to calculate weighted mean difference (WMD) with 95％ confidence interval (CI). RESULTS Six trials were included, with 1405 participants, including 597 patients with ISH and 808 patients with CH. Mean fol-low-up was five months. The reduction of 24-hour ambulatory SBP was significantly greater for the CH patients than the ISH pa-tients (WMD = 3.89, 95％ CI: 2.32–5.45, P < 0.0001). RDN also showed a greater reduction in office SBP in the CH patients compa-red to the ISH patients (WMD = 10.24, 95％ CI: 4.24–15.74, P = 0.0003). And the effect was independent of age, length of follow-up, and ablation device. CONCLUSIONS RDN provides superior blood pressure control in the CH patients compared with the ISH patients, and the CH patients may be the best suitable population for which RDN is indicated.
机标关键词：meta-analysishypertensionsystolicreviewwithdenervationeffectisolated
论文发表日期：2023-02-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 121-129 )