Triglyceride glucose index predicts in-hospital mortality in patients with ST-segment elevation myocardial infarction who underwent primary angiography
Rui FU1
Yan-Yan ZHAO2
Kong-Yong CUI1
Jin-Gang YANG3
Hai-Yan XU3
Dong YIN1
Wei-Hua SONG1
Hong-Jian WANG1
Cheng-Gang ZHU1
Lei FENG1
Zhi-Fang WANG4
Qing-Sheng WANG5
Ye LU2
Ke-Fei DOU1
Yue-Jin YANG3
CAMI Re-gistry Investigators
1.Cardiometabolic Medicine Center,Department of Cardiology,Fuwai Hospital,National Center for Cardiovascular Diseases,State Key Laboratory of Cardiovascular Disease,National Clinical Research Center for Cardiovascular Dis-eases,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China2.Medical Research&Biometrics Center,Fuwai Hospital,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China3.Coronary Heart Disease Center,Department of Cardiology,Fuwai Hospital,National Center for Cardiovascular Diseases,State Key Laboratory of Cardiovascular Disease,National Clinic-al Research Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical Col-lege,Beijing,China4.Department of Cardiology,Xinxiang Central Hospital,the Fourth Clinical College of Xinxiang Medical University,Henan Province,China5.Department of Cardiology,Qinhuangdao First Hospital,Hebei Province,China
摘要：OBJECTIVES To assess the correlation between triglyceride glucose (TyG) index and in-hospital mortality in patients with ST-segment elevation myocardial infarction (STEMI). METHODS A total of 2190 patients with STEMI who underwent primary angiography within 12 h from symptom onset were selected from the prospective, nationwide, multicenter CAMI registry. TyG index was calculated with the formula: Ln [fasting triglycerides (mmol/L) × fasting glucose (mmol/L)/2]. Patients were divided into three groups according to the tertiles of TyG index. The primary endpoint was in-hospital mortality. RESULTS Overall, 46 patients died during hospitalization, in-hospital mortality was 1.5％, 2.2％, 2.6％ for tertile 1, tertile 2, and tertile 3, respectively. However, TyG index was not significantly correlated with in-hospital mortality in single-variable logistic regression analysis. Nonetheless, after adjusting for age and sex, TyG index was significantly associated with higher mortality when regarded as a continuous variable (adjusted OR = 1.75, 95％ CI: 1.16-2.63) or categorical variable (tertile 3 vs. tertile 1: adjus-ted OR = 2.50, 95％ CI: 1.14-5.49). Furthermore, TyG index, either as a continuous variable (adjusted OR = 2.54, 95％ CI: 1.42-4.54) or categorical variable (tertile 3 vs. tertile 1: adjusted OR = 3.57, 95％ CI: 1.24-10.29), was an independent predictor of in-hospital mortality after adjusting for multiple confounders in multivariable logistic regression analysis. In subgroup analysis, the pro-gnostic effect of high TyG index was more significant in patients with body mass index < 18.5 kg/m2 (Pinteraction = 0.006). CONCLUSIONS This study showed that TyG index was positively correlated with in-hospital mortality in STEMI patients who underwent primary angiography, especially in underweight patients.
机标关键词：st-segmentangiographyglucoseindexwithelevationin-hospitalinfarction
论文发表日期：2023-03-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 185-194 )