Growth differentiation factor 15 predicts cardiovascular events in stable coronary artery disease
Juan WANG1
Li-Na HAN2
Dao-Sheng AI3
Xin-Yu WANG1
Wan-Jing ZHANG1
Xiao-Rong XU1
Hong-Bin LIU2
Jing ZHANG1
Pan WANG1
Xu LI1
Mu-Lei CHEN1
1.Heart Center of Beijing Chao-Yang Hospital,Capital Medical University,Beijing Key Laboratory of Hypertension,Bei-jing,China2.Department of Cardiology,the Second Medical Center,National Clinical Research Center for Geriatric Diseases,Chinese PLA General Hospital,Beijing,China3.Academy for Advanced Interdisciplinary Studies,Peking University National Institute of Biological Sciences,Zhongguancun Life Science Park,Tsinghua University,Beijing,China
摘要：BACKGROUND Growth differentiation factor 15(GDF-15)has been explored as a potential biomarker for various inflammat-ory diseases and cardiovascular events.This study aimed to assess the predictive role of GDF-15 levels in cardiovascular events and all-cause mortality,considering traditional risk factors and other biomarkers. METHODS A prospective study was conducted and 3699 patients with stable coronary artery disease(CAD)were enrolled in-to the research.Baseline GDF-15 levels were measured.Median follow-up was 3.1 years during the study.We analyzed clinical variables and several biomarkers.Multivariable Cox regression analysis was performed to evaluate prognostic performance of GDF-15 levels in predicting myocardial infarction(MI),heart failure,stroke,cardiovascular death,and non-cardiovascular death.RESULTS Baseline GDF-15 levels for 3699 patients were grouped by quartile(≤1153,1153-1888,1888-3043,＞3043 ng/L).Hig-her GDF-15 levels were associated with older age,male gender,history of hypertension,and elevated levels of N-terminal pro B-type natriuretic peptide(NT-pro BNP),soluble suppression of tumorigenesis-2(sST2),and creatine(each with P＜0.001).Adjust-ing for established risk factors and biomarkers in Cox proportional hazards models,a 1 standard deviation(SD)increase in GDF-15 was associated with elevated risk of clinical events[hazard ratio(HR)= 2.18,95％confidence interval(CI):(1.52-3.11)],includ-ing:MI[HR = 2.83 95％CI:(1.03-7.74)],heart failure[HR = 2.71 95％CI:(1.18-6.23)],cardiovascular and non-cardiovascular death[HR = 2.48,95％CI(1.49-4.11)]during the median follow up of 3.1 years.CONCLUSIONS Higher levels of GDF-15 consistently provides prognostic information for cardiovascular events and all cause death,independent of clinical risk factors and other biomarkers.GDF-15 could be considered as a valuable addition to future risk prediction model in secondary prevention for predicting clinical events in patient with stable CAD.
机标关键词：stablegrowtharterycardiovascularcoronarydifferentiationdiseaseevents
论文发表日期：2023-07-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：11( 527-537 )